Phagocytosis: Sweet Repulsions via the Glycocalyx

Sophia Maschalidi¹, Kodi S Ravichandran²

Affiliations

¹ Unit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
² Unit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; The Center for Cell Clearance, University of Virginia, Charlottesville, VA, USA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, USA. Electronic address: Ravi@virginia.edu.

PMID: 33434480
DOI: 10.1016/j.cub.2020.10.066

Free article

Editorial

Phagocytosis: Sweet Repulsions via the Glycocalyx

Sophia Maschalidi et al. Curr Biol. 2021.

Free article

. 2021 Jan 11;31(1):R20-R22.

doi: 10.1016/j.cub.2020.10.066.

Authors

Sophia Maschalidi¹, Kodi S Ravichandran²

Affiliations

¹ Unit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
² Unit for Cell Clearance in Health and Disease, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; The Center for Cell Clearance, University of Virginia, Charlottesville, VA, USA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, USA. Electronic address: Ravi@virginia.edu.

PMID: 33434480
DOI: 10.1016/j.cub.2020.10.066

Abstract

New work shows that the glycocalyx meshwork on the surface of macrophages prevents phagocytic receptors from binding their ligands by two means - electrostatic charge and steric hindrance. Components of this barrier are present on pathogenic and malignant targets that elude phagocytosis.

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An Acquired and Endogenous Glycocalyx Forms a Bidirectional "Don't Eat" and "Don't Eat Me" Barrier to Phagocytosis.
Imbert PRC, Saric A, Pedram K, Bertozzi CR, Grinstein S, Freeman SA. Imbert PRC, et al. Curr Biol. 2021 Jan 11;31(1):77-89.e5. doi: 10.1016/j.cub.2020.09.082. Epub 2020 Oct 22. Curr Biol. 2021. PMID: 33096038 Free PMC article.

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Phagocytosis: Sweet Repulsions via the Glycocalyx

Affiliations

Phagocytosis: Sweet Repulsions via the Glycocalyx

Authors

Affiliations

Abstract

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