Hypoxia: Uncharged tRNA to the Rescue!
- PMID: 33434482
- DOI: 10.1016/j.cub.2020.10.067
Hypoxia: Uncharged tRNA to the Rescue!
Abstract
A new study has identified genes that protect Caenorhabditis elegans from hypoxic stress. Genomic approaches and whole-organism proteomics reveal a regulatory interaction between a threonyl-tRNA synthetase and ribosome biogenesis that modulates global translation and hypoxic sensitivity.
Copyright © 2020 Elsevier Inc. All rights reserved.
Comment on
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Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation.Curr Biol. 2021 Jan 11;31(1):128-137.e5. doi: 10.1016/j.cub.2020.10.001. Epub 2020 Nov 5. Curr Biol. 2021. PMID: 33157031 Free PMC article.
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