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Comment
. 2021 Jan 11;39(1):19-21.
doi: 10.1016/j.ccell.2020.12.020.

Gluing Proteins for Targeted Degradation

Mikihiko Naito  1 , Shigeo Murata  2
Affiliations
Free article
Comment

Gluing Proteins for Targeted Degradation

Mikihiko Naito et al. Cancer Cell. .
Free article

Abstract

Targeted protein degradation is an emerging technology for drug development. An article published in Nature reported a novel mechanism of targeted protein degradation triggered by small-molecule-induced polymerization of the oncogenic transcription factor BCL6.

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Conflict of interest statement

Declarations of Interest M.N. is a project professor supported by Eisai and a scientific advisor of Ubience. S.M. declares no competing interests.

Comment on

  • Small-molecule-induced polymerization triggers degradation of BCL6.
    Słabicki M, Yoon H, Koeppel J, Nitsch L, Roy Burman SS, Di Genua C, Donovan KA, Sperling AS, Hunkeler M, Tsai JM, Sharma R, Guirguis A, Zou C, Chudasama P, Gasser JA, Miller PG, Scholl C, Fröhling S, Nowak RP, Fischer ES, Ebert BL. Słabicki M, et al. Nature. 2020 Dec;588(7836):164-168. doi: 10.1038/s41586-020-2925-1. Epub 2020 Nov 18. Nature. 2020. PMID: 33208943 Free PMC article.

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