Hydroxychloroquine early in pregnancy and risk of birth defects: absence of evidence is not the same as evidence of absence

Affiliations

¹ Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont St., Suite 3030, Boston, MA 02120; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address: khuybrechts@bwh.harvard.edu.
² Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
³ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

Comment

Krista F Huybrechts et al. Am J Obstet Gynecol. 2021 May.

. 2021 May;224(5):549-550.

doi: 10.1016/j.ajog.2020.12.1219. Epub 2021 Jan 9.

¹ Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont St., Suite 3030, Boston, MA 02120; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address: khuybrechts@bwh.harvard.edu.
² Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
³ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

No abstract available

Comment on

Hydroxychloroquine early in pregnancy and risk of birth defects.
Huybrechts KF, Bateman BT, Zhu Y, Straub L, Mogun H, Kim SC, Desai RJ, Hernandez-Diaz S. Huybrechts KF, et al. Am J Obstet Gynecol. 2021 Mar;224(3):290.e1-290.e22. doi: 10.1016/j.ajog.2020.09.007. Epub 2020 Sep 19. Am J Obstet Gynecol. 2021. PMID: 32961123 Free PMC article.
Hydroxychloroquine early in pregnancy and risk of birth defects: don't throw out the baby with the bathwater.
Bermas BL, Chambers C. Bermas BL, et al. Am J Obstet Gynecol. 2021 May;224(5):548-549. doi: 10.1016/j.ajog.2020.12.1218. Epub 2021 Jan 9. Am J Obstet Gynecol. 2021. PMID: 33434555 Free PMC article. No abstract available.