Signaling Pathway Mediating Myeloma Cell Growth and Survival

doi:10.3390/cancers13020216

Review

. 2021 Jan 8;13(2):216.

doi: 10.3390/cancers13020216.

Signaling Pathway Mediating Myeloma Cell Growth and Survival

Teru Hideshima¹, Kenneth C Anderson¹

Affiliations

Affiliation

¹ Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02446, USA.

PMID: 33435632
PMCID: PMC7827005
DOI: 10.3390/cancers13020216

Review

Signaling Pathway Mediating Myeloma Cell Growth and Survival

Teru Hideshima et al. Cancers (Basel). 2021.

. 2021 Jan 8;13(2):216.

doi: 10.3390/cancers13020216.

Authors

Teru Hideshima¹, Kenneth C Anderson¹

Affiliation

¹ Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02446, USA.

PMID: 33435632
PMCID: PMC7827005
DOI: 10.3390/cancers13020216

Abstract

The multiple myeloma (MM) bone marrow (BM) microenvironment consists of different types of accessory cells. Both soluble factors (i.e., cytokines) secreted from these cells and adhesion of MM cells to these cells play crucial roles in activation of intracellular signaling pathways mediating MM cell growth, survival, migration, and drug resistance. Importantly, there is crosstalk between the signaling pathways, increasing the complexity of signal transduction networks in MM cells in the BM microenvironment, highlighting the requirement for combination treatment strategies to blocking multiple signaling pathways.

Keywords: bone marrow microenvironment; cell adhesion; cytokine; multiple myeloma; signal transduction.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Activation of signaling pathways (selected) in MM cells in the BM microenvironment.

**Figure 2**
Cell adhesion-induced activation of signaling pathways.

See this image and copyright information in PMC

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References

1. Hideshima T., Mitsiades C., Tonon G., Richardson P.G., Anderson K.C. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat. Rev. Cancer. 2007;7:585–598. doi: 10.1038/nrc2189. - DOI - PubMed
1. Hideshima T., Podar K., Chauhan D., Anderson K.C. Cytokines and signal transduction. Best Pract. Res. Clin. Haematol. 2005;18:509–524. doi: 10.1016/j.beha.2005.01.003. - DOI - PubMed
1. Podar K., Anderson K.C. The pathophysiological role of VEGF in hematological malignancies: Therapeutic implications. Blood. 2005;105:1383–1395. doi: 10.1182/blood-2004-07-2909. - DOI - PubMed
1. Zhu D., Wang Z., Zhao J.J., Calimeri T., Meng J., Hideshima T., Fulciniti M., Kang Y., Ficarro S.B., Tai Y.T., et al. The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat. Med. 2015;21:572–580. doi: 10.1038/nm.3867. - DOI - PMC - PubMed
1. Jurczyszyn A., Czepiel J., Biesiada G., Gdula-Argasinska J., Cibor D., Owczarek D., Perucki W., Skotnicki A.B. HGF, sIL-6R and TGF-beta1 Play a Significant Role in the Progression of Multiple Myeloma. J. Cancer. 2014;5:518–524. doi: 10.7150/jca.9266. - DOI - PMC - PubMed

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[1] Hideshima T., Mitsiades C., Tonon G., Richardson P.G., Anderson K.C. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat. Rev. Cancer. 2007;7:585–598. doi: 10.1038/nrc2189. - DOI - PubMed

[2] Hideshima T., Mitsiades C., Tonon G., Richardson P.G., Anderson K.C. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat. Rev. Cancer. 2007;7:585–598. doi: 10.1038/nrc2189. - DOI - PubMed

[3] Hideshima T., Podar K., Chauhan D., Anderson K.C. Cytokines and signal transduction. Best Pract. Res. Clin. Haematol. 2005;18:509–524. doi: 10.1016/j.beha.2005.01.003. - DOI - PubMed

[4] Hideshima T., Podar K., Chauhan D., Anderson K.C. Cytokines and signal transduction. Best Pract. Res. Clin. Haematol. 2005;18:509–524. doi: 10.1016/j.beha.2005.01.003. - DOI - PubMed

[5] Podar K., Anderson K.C. The pathophysiological role of VEGF in hematological malignancies: Therapeutic implications. Blood. 2005;105:1383–1395. doi: 10.1182/blood-2004-07-2909. - DOI - PubMed

[6] Podar K., Anderson K.C. The pathophysiological role of VEGF in hematological malignancies: Therapeutic implications. Blood. 2005;105:1383–1395. doi: 10.1182/blood-2004-07-2909. - DOI - PubMed

[7] Zhu D., Wang Z., Zhao J.J., Calimeri T., Meng J., Hideshima T., Fulciniti M., Kang Y., Ficarro S.B., Tai Y.T., et al. The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat. Med. 2015;21:572–580. doi: 10.1038/nm.3867. - DOI - PMC - PubMed

[8] Zhu D., Wang Z., Zhao J.J., Calimeri T., Meng J., Hideshima T., Fulciniti M., Kang Y., Ficarro S.B., Tai Y.T., et al. The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat. Med. 2015;21:572–580. doi: 10.1038/nm.3867. - DOI - PMC - PubMed

[9] Jurczyszyn A., Czepiel J., Biesiada G., Gdula-Argasinska J., Cibor D., Owczarek D., Perucki W., Skotnicki A.B. HGF, sIL-6R and TGF-beta1 Play a Significant Role in the Progression of Multiple Myeloma. J. Cancer. 2014;5:518–524. doi: 10.7150/jca.9266. - DOI - PMC - PubMed

[10] Jurczyszyn A., Czepiel J., Biesiada G., Gdula-Argasinska J., Cibor D., Owczarek D., Perucki W., Skotnicki A.B. HGF, sIL-6R and TGF-beta1 Play a Significant Role in the Progression of Multiple Myeloma. J. Cancer. 2014;5:518–524. doi: 10.7150/jca.9266. - DOI - PMC - PubMed

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Signaling Pathway Mediating Myeloma Cell Growth and Survival

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Signaling Pathway Mediating Myeloma Cell Growth and Survival

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