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Comment
. 2021 Apr;18(4):790-791.
doi: 10.1038/s41423-020-00631-2. Epub 2021 Jan 12.

γδ T cells, Tregs and epithelial cells interact with IL-33 in the lung

Julie Darrigues  1 , Julie C Ribot  2
Affiliations
Comment

γδ T cells, Tregs and epithelial cells interact with IL-33 in the lung

Julie Darrigues et al. Cell Mol Immunol. 2021 Apr.
No abstract available

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Figures

Fig. 1
Fig. 1
Epithelial-immune cross talk in the lung upon inflammation. Environmental insults induce a type 2 immune response (namely, by activating innate lymphoid cells (ILC2s) and Th2 CD4+ T cells), which promotes the recruitment of eosinophils and mediates tissue damage. These insults also activate the production of IL-17A by γδ T cells, which enhances the production of epithelial IL-33, as previously demonstrated during influenza infection. IL-33 induces the proliferation of ST2+ Tregs, which in turn inhibit the type 2 response, limit the accumulation of γδ17 T cells through the secretion of IL-35, as reported in a model of HDM-induced allergy, and promote tissue repair through the production of amphiregulin.
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