Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan-Feb;37(1):109-113.
doi: 10.12669/pjms.37.1.3666.

Genetic polymorphism of the prostasin gene in hypertensive pregnant Pakistani females

Saima Ejaz  1 , Anwar Ali  2 , Sumaira Riffat  3 , Atif Mahmood  4 , Kamran Azim  5
Affiliations

Genetic polymorphism of the prostasin gene in hypertensive pregnant Pakistani females

Saima Ejaz et al. Pak J Med Sci. 2021 Jan-Feb.

Abstract

Objective: The study was performed to investigate the association of hypertension in pregnancy with prostasin gene polymorphism in Pakistani females.

Methods: This case-control study was performed at University of Karachi, Pakistan from April 2018 to May 2019. A total of 160 females, including 90 hypertensives and 70 healthy pregnant females, were recruited by purposive sampling after obtaining informed written consent. Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).

Results: The frequencies of the TC and CC genotypes were higher in hypertensive pregnant females compared to healthy controls. A significant difference was evident for CC (P=0.012) genotype; however, no significant difference was observed for TC (P=0.49) and TT genotypes (P=0.06) between control and hypertensive groups. The adjusted odds ratio for CC genotype was 6.2 (P=0.025) and 1.48 (P=0.44) for TC genotype compared to the TT genotype. There was a significantly higher prevalence of the C allele of the prostasin gene at rs12597511 in the hypertensive group, suggesting that this allele is a risk factor for hypertension and cardiovascular diseases.

Conclusion: C allele at rs12597511 of prostasin gene demonstrate as a risk factor for having hypertension in pregnancy.

Keywords: Epithelial Sodium Channel; Hypertension; Prostasin.

PubMed Disclaimer

Figures

Fig.1
Fig.1
Gel electrophoresis of PCR-RFLP of Prostasin Gene polymorphism in 6% agarose gel.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Karen M, Basky T, Veronica G, Anna R, Alessia M, Asma K. Hypertensive Disorders of Pregnancy and Future Cardiovascular Health. Front Cardiovasc Med. 2020;7:59–65. doi:10.3389/fcvm.2020.00059. - PMC - PubMed
    1. Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global Disparities of Hypertension Prevalence and Control:A Systematic Analysis of Population-Based Studies from 90 Countries. Circulation. 2016;134(6):441–450. doi:10.1161/CIRCULATIONAHA.115.018912. - PMC - PubMed
    1. Battarbee AN, Sinkey RG, Harper LM, Oparil S, Tita ATN. Chronic hypertension in pregnancy. Am J Obstet Gynecol. 2020;222(6):532–541. doi:10.1016/j.ajog.2019.11.1243. - PubMed
    1. Oliveira-Paula GH, Pereira SC, Tanus-Santos JE, Lacchini R. Pharmacogenomics and Hypertension:Current Insights. Pharmgenomics Pers Med. 2019;12:341–359. doi:10.2147/PGPM.S230201. - PMC - PubMed
    1. Polychronopoulou E, Braconnier P, Burnier M. New Insights on the Role of Sodium in the Physiological Regulation of Blood Pressure and Development of Hypertension. Front Cardiovasc Med. 2019;6:136. doi:10.3389/fcvm.2019.00136. - PMC - PubMed

LinkOut - more resources