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Review
. 2020 Dec 24;11(12):1008-1017.
doi: 10.5306/wjco.v11.i12.1008.

Fluoropyrimidine-induced cardiotoxicity

Andrada Larisa Deac  1 , Claudia Cristina Burz  2 , Ioana Corina Bocsan  3 , Anca Dana Buzoianu  3
Affiliations
Review

Fluoropyrimidine-induced cardiotoxicity

Andrada Larisa Deac et al. World J Clin Oncol. .

Abstract

Cardio-oncology is a discipline based on early screening, monitoring, and treating chemotherapy-induced cardiotoxicity. There are many chemotherapeutics known for their cardiac toxic effects, including fluoropyrimidines. Fluoropyrimidine represents the cornerstone of many types of cancer and each year almost two million cancer patients undergo this treatment. Fluoropyrimidine-induced cardiotoxicity can be manifested in several forms, from angina pectoris to sudden death. This paper is a review of how the cardiotoxicity of fluoropyrimidines is presented, the mechanisms of its occurrence, its diagnosis, and management.

Keywords: Antidote; Cancer treatments; Cardiotoxicity; Fluoropyrimidines; Prevention; Rechallenge.

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Conflict of interest statement

Conflict-of-interest statement: No conflict of interest.

Figures

Figure 1
Figure 1
Proposed mechanism of fluoropyrimidine-induced cardiotoxicity.
See this image and copyright information in PMC

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