Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov 24;10(6):686-691.
doi: 10.4103/jispcd.JISPCD_316_20. eCollection 2020 Nov-Dec.

Efficacy of Lignocaine with Buprenorphine versus Lignocaine in the Management of Postoperative Pain after Minor Oral Surgical Procedures: A Systematic Review and Meta-analysis

Anupam Singh  1 , Srikanth Gadicherla  1 , Komal Smriti  2 , Kalyana C Pentapati  3
Affiliations
Review

Efficacy of Lignocaine with Buprenorphine versus Lignocaine in the Management of Postoperative Pain after Minor Oral Surgical Procedures: A Systematic Review and Meta-analysis

Anupam Singh et al. J Int Soc Prev Community Dent. .

Abstract

We aimed to review the efficacy of lignocaine with buprenorphine versus lignocaine alone in the management of postoperative pain after minor oral surgical procedures. Randomized controlled trials evaluating the efficacy of use of lignocaine with buprenorphine versus lignocaine for intra-oral procedures were included by searching multiple databases. Outcomes assessed were onset of the time of anesthesia in seconds, duration of postoperative analgesia, postoperative pain (maximal follow-up), the number of rescue analgesics required, and adverse events. The search strategy yielded 167 publications for the title and abstract screening out of which only two trials were included for full-text screening. There was considerable heterogeneity among the included studies with regards to the outcomes assessed. The need for rescue analgesics was the only outcome that was included for meta-analyses. Forest plot showed that lignocaine with buprenorphine compared to lignocaine showed a significantly lower requirement of rescue analgesics (-0.22[-2.9,-1.55]). No trial reported any adverse effects. The results show that lignocaine with buprenorphine is effective in reducing the number of rescue analgesics required by the patient.

Keywords: Analgesia; anesthesia; buprenorphine; lignocaine; postoperative pain; rescue analgesics.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Detailing of the included studies for systematic review and meta-analysis as per PRISMA guidelines
Figure 2
Figure 2
Risk of bias summary: review authors’ judgments about each risk of bias item for each included study
Figure 3
Figure 3
Forest plot for the outcome need for rescue analgesics
See this image and copyright information in PMC

References

    1. Oginni FO, Ugboko VI, Assam E, Ogunbodede EO. Postoperative complaints following impacted mandibular third molar surgery in Ile-Ife, Nigeria. Sadj. 2002;57:264–8. - PubMed
    1. McGrath C, Comfort MB, Lo EC, Luo Y. Changes in life quality following third molar surgery––the immediate postoperative period. Br Dent J. 2003;194:265–8; discussion 261. - PubMed
    1. Meechan JG. Infiltration anesthesia in the mandible. Dent Clin North Am. 2010;54:621–9. - PubMed
    1. Ueno T, Tsuchiya H, Mizogami M, Takakura K. Local anesthetic failure associated with inflammation: Verification of the acidosis mechanism and the hypothetic participation of inflammatory peroxynitrite. J Inflamm Res. 2008;1:41–8. - PMC - PubMed
    1. Stein C. Peripheral mechanisms of opioid analgesia. Anesth Analg. 1993;76:182–91. - PubMed