Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Nov 2:34:147.
doi: 10.34171/mjiri.34.147. eCollection 2020.

COVID-19: Case fatality and ACE2 inhibitors treatment concerns in patients with comorbidities

Rokhsareh Aghili  1 , Maryam Honardoost  1   2 , Mohammad E Khamseh  1
Affiliations
Review

COVID-19: Case fatality and ACE2 inhibitors treatment concerns in patients with comorbidities

Rokhsareh Aghili et al. Med J Islam Repub Iran. .

Abstract

The Corona Virus Disease 2019 (COVID-19) outbreak is becoming pandemic with the highest mortality in patients with associated comorbidities. These RNA viruses containing 4 structural proteins usually use spike protein to enter the host cell. Angiotensin-converting enzyme 2 (ACE2) acts as a host receptor for the virus. Therefore, medications acting on renin-angiotensin-aldosterone system can lead to serious complications, especially in patients with diabetes and hypertension. To avoid this, other potential treatment modalities should be used in COVID-19 patients with associated comorbidities.

Keywords: ACE2 inhibitors; Associated comorbidities; COVID-19; Treatment; Type 2 diabetes.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: None declared

Similar articles

See all similar articles

Cited by

References

    1. Chen Z, Zhang Q, Lu Y, Guo Z, Zhang X, Zhang W. et al. Distribution of the COVID-19 epidemic and correlation with population emigration from wuhan, China. Chin Med J. 2020 - PMC - PubMed
    1. Boldog P, Tekeli T, Vizi Z, Dénes A, Bartha FA, Röst G. Risk assessment of novel coronavirus COVID-19 outbreaks outside China. J Clin Med. 2020;9(2):571. - PMC - PubMed
    1. Honardoost M, Janani L, Aghili R, Emami Z, Khamseh ME. The Association Between Presence of Comorbidities and COVID-19 Severity; A Systematic Review and Meta-Analysis. prerrint. 2020. - PMC - PubMed
    1. de Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nature Reviews Microbiology. 2016;14(8):523. - PMC - PubMed
    1. Paraskevis D, Kostaki EG, Magiorkinis G, Panayiotakopoulos G, Sourvinos G, Tsiodras S. Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event. Infect Genet Evol. 2020;79:104212. - PMC - PubMed

LinkOut - more resources