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. 2020 Dec;8(23):1562.
doi: 10.21037/atm-20-2813a.

Cross-sectional analysis of the association between serum uric acid levels and handgrip strength among Chinese adults over 45 years of age

Liqian Xu  1   2 , Yuxia Jing  3 , Chen Zhao  4 , Yichen Yang  1   2 , Ji Yang  1   2 , Wenjing Zhou  1   2 , Qin Zhang  1   2 , Zhaodi Wang  1   2 , Yunmei Yang  1   2
Affiliations

Cross-sectional analysis of the association between serum uric acid levels and handgrip strength among Chinese adults over 45 years of age

Liqian Xu et al. Ann Transl Med. 2020 Dec.

Abstract

Background: Sarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress; uric acid (UA) has strong antioxidant properties. This study aimed to examine if the serum UA level is associated with handgrip strength (HGS), which is a useful indicator of sarcopenia among Chinese participants aged over 45.

Methods: Our study included 992 eligible participants (583 males and 409 females). Based on serum UA quartiles and gender, the participants were divided into 8 groups. HGS was measured in kilograms using an electronic dynamometer. Face-to-face visits and fasting blood analyses were performed to determine the serum UA levels and various covariates. Univariate analysis of variance (ANOVA) and covariance (ANCOVA) was conducted to analyze the linear or quadratic trend between the UA levels and grip strength.

Results: Participants were grouped according to UA quartiles by gender. In both genders, ANOVA showed an inverted J-shaped association between serum UA levels and HGS (P for quadratic trend =0.004 in men, P for quadratic trend =0.003 in women). After adjusting for potential confounders, the association between the UA quartiles and HGS was unchanged, irrespective of gender.

Conclusions: The results suggest that a specific range of serum UA levels may be associated with better HGS among Chinese adults aged over 45.

Keywords: Uric acid (UA); handgrip strength (HGS); sarcopenia.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-2813a). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Scatter plots for UA against handgrip strength by gender. UA, uric acid.
Figure 2
Figure 2
Univariate analysis of variance for the association between the quartiles of UA and HGS (A: men; B: women). UA, uric acid; HGS, handgrip strength.
See this image and copyright information in PMC

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