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. 2020 Dec;8(23):1579.
doi: 10.21037/atm-20-4195.

Design of the Shunyi study on cardiovascular disease and age-related brain changes: a community-based, prospective, cohort study

Fei Han  1 , Li-Xin Zhou  1 , Jun Ni  1 , Ming Yao  1 , Fei-Fei Zhai  1 , Yong-Tai Liu  2 , Wei Wu  2 , Hua-Dan Xue  3 , Ming-Li Li  3 , Meng Yang  4 , Qing Dai  4 , Li-Ying Cui  1 , Zheng-Yu Jin  3 , Yi-Cheng Zhu  1 , Shu-Yang Zhang  2
Affiliations

Design of the Shunyi study on cardiovascular disease and age-related brain changes: a community-based, prospective, cohort study

Fei Han et al. Ann Transl Med. 2020 Dec.

Abstract

Background: Rapid economic growth and increasing lifespan have contributed to an increasing burden of chronic non-communicable diseases in China. Population-based studies focusing on cardiovascular disease and age-related brain changes, with extensive clinical, genetic, and imaging data as well as a comprehensive evaluation of brain function are lacking in China. The Shunyi cohort study aimed to investigate the determinants and consequences of cardiovascular disease and age-related brain alterations among individuals residing in a rural area of Beijing.

Methods: This prospective, community-based study included individuals aged 35 years and older living in five villages in Shunyi, a rural district located 20 miles from urban Beijing. A total of 1,586 individuals were enrolled between June 2013 and September 2014. Biological samples and brain magnetic resonance images were collected along with baseline clinical data through face-to-face interviews. Whole exome sequencing and quantitative assessments of cognitive and motor function were performed.

Results: Among the 1,586 participants included, 40% were men, and the mean age of the cohort was 56.7±10.0 years. This population had a relatively low education level. A heavy burden of vascular risk factors with a low control rate was observed in the Shunyi population. Since 2017, the cohort has been followed up annually. As of October 2019, we had failed to obtain the follow-up data of five participants.

Conclusions: With an extensive range of clinical, genetic, and imaging data, the Shunyi cohort study has the potential to contribute significantly towards identifying the causes and consequences of cardiovascular disease and age-related brain changes in older people in China.

Keywords: China; Community-based; brain function; brain structure; cardiovascular disease.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-4195). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Location of the Shunyi district in China.
Figure 2
Figure 2
Flowchart of participant recruitment.
See this image and copyright information in PMC

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