Updates from the 2020 World Health Organization Classification of Soft Tissue and Bone Tumours
- PMID: 33438273
- DOI: 10.1111/his.14265
Updates from the 2020 World Health Organization Classification of Soft Tissue and Bone Tumours
Abstract
The fifth edition of the World Health Organization (WHO) classification of soft tissue and bone tumours was published in May 2020. This 'Blue Book', which is also available digitally for the first time, incorporates an array of new information on these tumours, amassed in the 7 years since the previous edition. Major advances in molecular characterisation have driven further refinements in classification and the development of ancillary diagnostic tests, and have improved our understanding of disease pathogenesis. Several new entities are also included. This review summarises the main changes introduced in the 2020 WHO classification for each subcategory of soft tissue and bone tumours.
Keywords: WHO; bone; sarcoma; soft tissue; tumour.
© 2020 John Wiley & Sons Ltd.
References
-
- Fletcher CDM, Bridge JA, Hogendoorn PCW et al. eds. World Health Organization classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press, 2013.
-
- Anderson WJ, Hornick JL. Immunohistochemical correlates of recurrent genetic alterations in sarcomas. Genes Chromosomes Cancer 2019; 58; 111-123.
-
- WHO Classification of Tumours Editorial Board eds. World Health Organization classification of soft tissue and bone tumours. 5th ed. Lyon: IARC Press, 2020.
-
- Marino-Enriquez A, Nascimento AF, Ligon AH et al. Atypical spindle cell lipomatous tumor: clinicopathologic characterization of 232 cases demonstrating a morphologic spectrum. Am. J. Surg. Pathol. 2017; 41; 234-244.
-
- Creytens D, Mentzel T, Ferdinande L et al. ‘Atypical’ pleomorphic lipomatous tumor: a clinicopathologic, immunohistochemical and molecular study of 21 cases, emphasizing its relationship to atypical spindle cell lipomatous tumor and suggesting a morphologic spectrum (atypical spindle cell/pleomorphic lipomatous tumor). Am. J. Surg. Pathol. 2017; 41; 1443-1455.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical