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Review
. 2021 Jan 13;23(2):16.
doi: 10.1007/s11912-020-01009-3.

Acute Myeloid Leukemia in Children: Emerging Paradigms in Genetics and New Approaches to Therapy

Shannon E Conneely  1 , Alexandra M Stevens  2
Affiliations
Review

Acute Myeloid Leukemia in Children: Emerging Paradigms in Genetics and New Approaches to Therapy

Shannon E Conneely et al. Curr Oncol Rep. .

Abstract

Purpose of review: Acute myeloid leukemia (AML) in children remains a challenging disease to cure with suboptimal outcomes particularly when compared to the more common lymphoid leukemias. Recent advances in the genetic characterization of AML have enhanced understanding of individualized patient risk, which has also led to the development of new therapeutic strategies. Here, we review key cytogenetic and molecular features of pediatric AML and how new therapies are being used to improve outcomes.

Recent findings: Recent studies have revealed an increasing number of mutations, including WT1, CBFA2T3-GLIS2, and KAT6A fusions, DEK-NUP214 and NUP98 fusions, and specific KMT2A rearrangements, which are associated with poor outcomes. However, outcomes are starting to improve with the addition of therapies such as gemtuzumab ozogamicin and FLT3 inhibitors, initially developed in adult AML. The combination of advanced risk stratification and ongoing improvements and innovations in treatment strategy will undoubtedly lead to better outcomes for children with AML.

Trial registration: ClinicalTrials.gov NCT03568994.

Keywords: Chemotherapy; Epigenetic; Immunotherapy; Outcomes; Risk stratification; Tyrosine kinase.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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