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. 2021 Sep;42(9):3663-3671.
doi: 10.1007/s10072-020-05008-x. Epub 2021 Jan 13.

Diabetes and impaired fasting glucose in a population-based sample of individuals aged 75 + years: associations with cognition, major depressive disorder, functionality and quality of life-the Pietà study

Ana Paula Borges Santos  1   2 , Lenita Zajdenverg  3 , Henrique Cerqueira Guimarães  2 , Rogério Gomes Beato  2 , Mariana Alves de Almeida  1   2 , Simone Rios Fonseca Ritter  2 , João Carlos Barbosa Machado  2 , Antônio Lucio Teixeira Jr  4 , Maira Tonidandel Barbosa  2   5 , Paulo Caramelli  6   7
Affiliations

Diabetes and impaired fasting glucose in a population-based sample of individuals aged 75 + years: associations with cognition, major depressive disorder, functionality and quality of life-the Pietà study

Ana Paula Borges Santos et al. Neurol Sci. 2021 Sep.

Abstract

Objectives: To investigate the rates of diabetes mellitus (DM) and impaired fasting glucose (IFG) in a population-based sample of individuals aged 75 + years old and their associations with cognitive performance, depression, functionality, and quality of life (QoL).

Study design: Overall, 350 people participated in the study. Assessments of cognition, mood, functionality and QoL were performed using the mini-mental state examination (MMSE), clock-drawing, category fluency tests, the Mini-International Neuropsychiatric Interview, Pfeffer's Functional Activities Questionnaire, and the WHO Quality of Life-Old (WHOQOL-OLD).

Results: IFG (ADA criteria) was identified in 42.1% of the sample, while the DM rate was 24.1%. Lack of knowledge of the DM diagnosis and lack of treatment occurred in 27% and 39% of the sample, respectively. Rates of dementia and depression, MMSE, category fluency scores, and previous cardiovascular events did not differ between the glycaemic groups. Individuals with DM performed worse on the clock-drawing test, functionality, and WHOQOL-OLD than the other participants. Individuals with IFG presented similar QoL and functionality when compared with the group without DM.

Conclusions: IFG and DM were common in this population-based sample aged 75 + years old, as were inadequate diagnoses and treatments of DM. DM individuals presented poor performance in the executive function test, functionality, and QoL. Further studies are recommended to investigate the value of an IFG diagnosis among the most elderly population.

Keywords: Dementia; Diabetes; Functionality; Impaired fasting glucose; Older adult; Quality of life.

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References

    1. Centers for disease control and prevention (2020) National diabetes statistics report. Centers for Disease Control and Prevention, Atlanta
    1. Shang Y, Marseglia A, Fratiglioni L, Welmer AK, Wang R, Wang HX, Xu W (2019) Natural history of prediabetes in older adults from a population-based longitudinal study. J Intern Med 286:326–340. https://doi.org/10.1111/joim.12920 - DOI - PubMed - PMC
    1. World Health Organization (2018) Global health estimates 2016: deaths by cause, age, sex, by country and by region, 2000–2016. World Health Organization, Geneva
    1. Chen S, Zhang Q, Dai G, Hu J, Zhu C, Su L, Wu X (2016) Association of depression with pre-diabetes, undiagnosed diabetes, and previously diagnosed diabetes: a meta-analysis. Endocrine 53:35–46. https://doi.org/10.1007/s12020-016-0869-x - DOI - PubMed
    1. Wang F, Wang S, Zong QQ, Zhang Q, Ng CH, Ungvari GS, Xiang YT (2019) Prevalence of comorbid major depressive disorder in type 2 diabetes: a meta-analysis of comparative and epidemiological studies. Diabet Med 36:961–969. https://doi.org/10.1111/dme.14042 - DOI - PubMed

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