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Review
. 2021 Mar;42(3):883-894.
doi: 10.1007/s10072-020-04981-7. Epub 2021 Jan 13.

Hereditary spastic paraplegia

Sireesha Murala  1 , Elanagan Nagarajan  2 , Pradeep C Bollu  3
Affiliations
Review

Hereditary spastic paraplegia

Sireesha Murala et al. Neurol Sci. 2021 Mar.

Abstract

Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders which involve the corticospinal tracts and present with distinct spasticity and weakness of the lower extremities. The estimated prevalence of HSP is around 1.8/100,000 cases for both autosomal dominant and autosomal recessive types. Classification of HSP is based on inheritance pattern, clinical phenotype, and molecular pathophysiological mechanisms. The most common neuropathological sign is the axonal degeneration involving the lateral corticospinal tracts in both the cervical and thoracic spinal cord. The target of this review article is to provide a comprehensive overview of the HSP classification, neuropathology, and differential diagnosis.

Keywords: Autosomal dominant HSP; Autosomal recessive HSP; Differential diagnosis; Hereditary spastic paraplegia; Treatment; X-linked.

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References

    1. Chrestian N, Dupré N, Gan-Or Z, Szuto A, Chen S, Venkitachalam A et al (2017) Clinical and genetic study of hereditary spastic paraplegia in Canada. 3(1):e122
    1. Koh K, Ishiura H, Tsuji S, Takiyama Y (2018) JASPAC: Japan Spastic Paraplegia Research Consortium. Brain Sci 8(8):153 - DOI
    1. Schüle R, Wiethoff S, Martus P, Karle KN, Otto S, Klebe S et al (2016) Hereditary spastic paraplegia: clinicogenetic lessons from 608 patients. 79(4):646–658
    1. Strümpell A (1880) Beiträge zur Pathologie des Rückenmarks. Archiv für Psychiatrie und Nervenkrankheiten 10(3):676–717 - DOI
    1. Strümpell A (1886) Ueber eine bestimmte Form der primären combinirten Systemerkrankung des Rückenmarks. Archiv für Psychiatrie und Nervenkrankheiten 17(1):217–238 - DOI

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