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. 1988 Jan;25(1):1-6.
doi: 10.1016/0161-5890(88)90084-3.

Studies on the specificity of the IgA-binding lectin, jacalin

D L Skea  1 , P Christopoulous, A G Plaut, B J Underdown
Affiliations

Studies on the specificity of the IgA-binding lectin, jacalin

D L Skea et al. Mol Immunol. 1988 Jan.

Abstract

The interactions of IgA with the jackfruit lectin, jacalin, were investigated with regard to the specificity of jacalin for species and subclasses of IgA. It was found that jacalin selectively bound to human IgA1, but not to human IgA2, mouse IgA or rat IgA. Binding studies with human IgA1 fragments produced by different IgA1 proteases revealed that jacalin bound to galactose-terminal oligosaccharides in the hinge region of human IgA1. Affinity chromatography employing jacalin-Sepharose provided a means to separate the subclasses of IgA in human whey.

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