Targeting Bacteria within Us to Diminish Infection and Autoimmunity
- PMID: 33440134
- DOI: 10.1016/j.immuni.2020.12.006
Targeting Bacteria within Us to Diminish Infection and Autoimmunity
Abstract
Antibiotics improve clinical outcomes independent of their antibacterial effects. In this issue of Immunity, Almeida et al. and Colaço et al. demonstrate that antibiotic impairment of mitochondrial ribosomes modulates both T-cell-dependent inflammation and host tolerance to infection.
Copyright © 2020 Elsevier Inc. All rights reserved.
Comment on
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Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection.Immunity. 2021 Jan 12;54(1):53-67.e7. doi: 10.1016/j.immuni.2020.09.011. Epub 2020 Oct 14. Immunity. 2021. PMID: 33058782 Free PMC article.
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Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.Immunity. 2021 Jan 12;54(1):68-83.e6. doi: 10.1016/j.immuni.2020.11.001. Epub 2020 Nov 24. Immunity. 2021. PMID: 33238133 Free PMC article.
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