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. 2021 Jan 12;54(1):9-11.
doi: 10.1016/j.immuni.2020.12.007.

IL-33 Changes Our "Gut Feelings" about Serotonin

Lewis W Yu  1 , Elaine Y Hsiao  2
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IL-33 Changes Our "Gut Feelings" about Serotonin

Lewis W Yu et al. Immunity. .
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Abstract

Many studies highlight direct interactions between immune cells and enteric neurons, but whether immune signals can indirectly modulate enteric function through neurotransmitter regulation is poorly understood. In this issue of Immunity, Chen et al. reveal how IL-33 induces intestinal serotonin to promote gut motility.

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