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. 2021 Jan 13;11(1):914.
doi: 10.1038/s41598-020-80131-5.

Urine biomarkers in ESSIC type 2 interstitial cystitis/bladder pain syndrome and overactive bladder with developing a novel diagnostic algorithm

Yuan-Hong Jiang  1 , Jia-Fong Jhang  1 , Yung-Hsiang Hsu  2 , Han-Chen Ho  3 , Ya-Hui Wu  1 , Hann-Chorng Kuo  4
Affiliations

Urine biomarkers in ESSIC type 2 interstitial cystitis/bladder pain syndrome and overactive bladder with developing a novel diagnostic algorithm

Yuan-Hong Jiang et al. Sci Rep. .

Abstract

This study aimed to investigate the diagnostic values of urine cytokines in interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB) patients, and to develop a novel diagnostic algorithm. Urine samples were collected from 40 IC/BPS, 40 OAB patients, and 30 controls. Commercially available multiplex immunoassays were used to analyze 31 targeted cytokines. Urine cytokine profiles were significantly different among study groups and controls. MIP-1β showed the highest sensitivity (92.2%) for identifying diseased study patients from controls. The cytokines with high diagnostic values for distinguishing between IC and OAB included IL-10, RANTES, eotaxin, CXCL10, IL-12p70, NGF, IL-6, IL-17A, MCP-1, and IL-1RA. The diagnostic algorithm was subsequently developed according to the diagnostic values obtained. MIP-1β was selected for the initial screening test to diagnose diseased patients and controls with diagnostic rates of 81.6% and 68.4%, respectively. As confirmation tests for IC/BPS, the diagnostic rates of eotaxin, CXCL10, and RANTES were 73.3%, 72.7%, and 69.7%, respectively. As the confirmation test for OAB, the diagnostic rate of IL-10 was 60%. Urine cytokine profiles of IC/BPS and OAB patients differed from those of controls and might be useful as biomarkers for diagnosis. A novel pilot diagnostic algorithm was developed based on these profiles.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Violin plots of significant cytokines with high diagnostic values for IC/BPS and OAB.
Figure 2
Figure 2
Preliminary novel diagnostic algorithm for distinguishing IC/BPS and OAB from controls based on diagnostic values.
See this image and copyright information in PMC

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