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. 2020 Nov 3;8(1):ofaa521.
doi: 10.1093/ofid/ofaa521. eCollection 2021 Jan.

Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19

Rosa Bellmann-Weiler  1 , Lukas Lanser  1 , Francesco Burkert  1 , Stefanie Seiwald  1 , Gernot Fritsche  1 , Sophie Wildner  1 , Andrea Schroll  1 , Sabine Koppelstätter  1 , Katharina Kurz  1 , Andrea Griesmacher  2 , Günter Weiss  1
Affiliations

Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19

Rosa Bellmann-Weiler et al. Open Forum Infect Dis. .

Abstract

This study evaluates the predictive value of circulating inflammatory markers, especially neopterin, in patients with coronavirus disease 2019 (COVID-19). Within this retrospective analysis of 115 hospitalized COVID-19 patients, elevated neopterin levels upon admission were significantly associated with disease severity, risk for intensive care unit admission, need for mechanical ventilation, and death. Therefore, neopterin is a reliable predictive marker in patients with COVID-19 and may help to improve the clinical management of patients.

Keywords: COVID-19; SARS-CoV-2; disease severity; neopterin; outcome.

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