BNCT for primary synovial sarcoma

Abstract

Synovial sarcoma is a rare tumor requiring new treatment methods. A 46-year-old woman with primary monophasic synovial sarcoma in the left thigh involving the sciatic nerve, declining surgery because of potential dysfunction of the affected limbs, received two courses of BNCT. The tumor thus reduced was completely resected with no subsequent recurrence. The patient is now able to walk unassisted, and no local recurrence has been observed, demonstrating the applicability of BNCT as adjuvant therapy for synovial sarcoma. Further study and analysis with more experience accumulation are needed to confirm the real impact of BNCT efficacy for its application to synovial sarcoma.

Keywords: (18)F-fluorodeoxyglucose positron emission tomography/computed tomography; 4-borono-2-(18)F-fluoro-l-phenylalanine positron emission tomography/computed tomography; Adjuvant therapy; Biphasic subtype; Boron neutron capture therapy (BNCT); Clinical treatment; Ki-67; L-type amino acid transporter 1; Monophasic subtype; Primary; Synovial sarcoma; p-borono-l-phenylalanine (BPA).