Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease

doi:10.3390/biomedicines9010072

. 2021 Jan 12;9(1):72.

doi: 10.3390/biomedicines9010072.

Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease

Anna Bonaterra-Pastra¹, Sofia Fernández-de-Retana¹, Andrea Rivas-Urbina², Núria Puig², Sònia Benítez², Olalla Pancorbo³, David Rodríguez-Luna³, Francesc Pujadas⁴, Maria Del Mar Freijo⁵, Silvia Tur⁶, Maite Martínez-Zabaleta⁷, Pere Cardona Portela⁸, Rocío Vera⁹, Lucia Lebrato-Hernández¹⁰, Juan F Arenillas^{11

12}, Soledad Pérez-Sánchez¹³, Joan Montaner^{1

10

13

14}, Jose Luis Sánchez-Quesada^{2

15}, Mar Hernández-Guillamon¹

Affiliations

¹ Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
² Cardiovascular Biochemistry Group, Research Institute of the Hospital de Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.
³ Stroke Research Group, Vall d'Hebron Research Institute, 08035 Barcelona, Spain.
⁴ Dementia Unit, Neurology Department, Vall d'Hebron Hospital, 08035 Barcelona, Spain.
⁵ Neurovascular Group, Biocruces Health Research Institute, 48903 Barakaldo, Spain.
⁶ Department of neurology, Son Espases University Hospital, 07010 Palma de Mallorca, Spain.
⁷ Department of Neurology, Donostia University Hospital, 20014 San Sebastián, Spain.
⁸ Department of Neurology, Bellvitge University Hospital, 08907 L'Hospitalet de Llobregat, Spain.
⁹ Stroke Unit-Department of Neurology, Ramon y Cajal University Hospital, 28034 Madrid, Spain.
¹⁰ Stroke Unit, Virgen del Rocío University Hospital, 41013 Sevilla, Spain.
¹¹ Stroke Program, Department of Neurology, Hospital Clínico Universitario, 47703 Valladolid, Spain.
¹² Clinical Neurosciences Research Group, Department of Medicine, University of Valladolid, 47702 Valladolid, Spain.
¹³ Department of Neurology, Virgen Macarena University Hospital, 41009 Sevilla, Spain.
¹⁴ Stroke Research Program, Insitute of Biomedicine of Sevilla, IBiS. 41013 Sevilla, Spain.
¹⁵ CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Spain.

PMID: 33445800
PMCID: PMC7828227
DOI: 10.3390/biomedicines9010072

Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease

Anna Bonaterra-Pastra et al. Biomedicines. 2021.

. 2021 Jan 12;9(1):72.

doi: 10.3390/biomedicines9010072.

Authors

Affiliations

¹ Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
² Cardiovascular Biochemistry Group, Research Institute of the Hospital de Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.
³ Stroke Research Group, Vall d'Hebron Research Institute, 08035 Barcelona, Spain.
⁴ Dementia Unit, Neurology Department, Vall d'Hebron Hospital, 08035 Barcelona, Spain.
⁵ Neurovascular Group, Biocruces Health Research Institute, 48903 Barakaldo, Spain.
⁶ Department of neurology, Son Espases University Hospital, 07010 Palma de Mallorca, Spain.
⁷ Department of Neurology, Donostia University Hospital, 20014 San Sebastián, Spain.
⁸ Department of Neurology, Bellvitge University Hospital, 08907 L'Hospitalet de Llobregat, Spain.
⁹ Stroke Unit-Department of Neurology, Ramon y Cajal University Hospital, 28034 Madrid, Spain.
¹⁰ Stroke Unit, Virgen del Rocío University Hospital, 41013 Sevilla, Spain.
¹¹ Stroke Program, Department of Neurology, Hospital Clínico Universitario, 47703 Valladolid, Spain.
¹² Clinical Neurosciences Research Group, Department of Medicine, University of Valladolid, 47702 Valladolid, Spain.
¹³ Department of Neurology, Virgen Macarena University Hospital, 41009 Sevilla, Spain.
¹⁴ Stroke Research Program, Insitute of Biomedicine of Sevilla, IBiS. 41013 Sevilla, Spain.
¹⁵ CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Spain.

PMID: 33445800
PMCID: PMC7828227
DOI: 10.3390/biomedicines9010072

Abstract

Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.

Keywords: Alzheimer’s disease; apolipoproteins; cerebral amyloid angiopathy; lipid profile; lipoprotein composition.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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[1] Vinters H.V. Emerging Concepts in Alzheimer’s Disease. Annu. Rev. Pathol. Mech. Dis. 2015;10:291–319. doi: 10.1146/annurev-pathol-020712-163927. - DOI - PubMed

[2] Vinters H.V. Emerging Concepts in Alzheimer’s Disease. Annu. Rev. Pathol. Mech. Dis. 2015;10:291–319. doi: 10.1146/annurev-pathol-020712-163927. - DOI - PubMed

[3] Charidimou A., Boulouis G., Gurol M.E., Ayata C., Bacskai B.J., Frosch M.P., Viswanathan A., Greenberg S.M. Emerging concepts in sporadic cerebral amyloid angiopathy. Brain. 2017;140:1829–1850. doi: 10.1093/brain/awx047. - DOI - PMC - PubMed

[4] Charidimou A., Boulouis G., Gurol M.E., Ayata C., Bacskai B.J., Frosch M.P., Viswanathan A., Greenberg S.M. Emerging concepts in sporadic cerebral amyloid angiopathy. Brain. 2017;140:1829–1850. doi: 10.1093/brain/awx047. - DOI - PMC - PubMed

[5] Arvanitakis Z., Leurgans S.E., Wang Z., Wilson R.S., Bennett D.A., Schneider J.A. Cerebral Amyloid Angiopathy Pathology and Cognitive Domains in Older Persons. Ann. Neurol. 2011;69:320–327. doi: 10.1002/ana.22112. - DOI - PMC - PubMed

[6] Arvanitakis Z., Leurgans S.E., Wang Z., Wilson R.S., Bennett D.A., Schneider J.A. Cerebral Amyloid Angiopathy Pathology and Cognitive Domains in Older Persons. Ann. Neurol. 2011;69:320–327. doi: 10.1002/ana.22112. - DOI - PMC - PubMed

[7] Greenberg S.M., Bacskai B.J., Hernandez-Guillamon M., Pruzin J., Sperling R., van Veluw S.J. Cerebral amyloid angiopathy and Alzheimer disease—One peptide, two pathways. Nat. Rev. Neurol. 2020;16:30–42. doi: 10.1038/s41582-019-0281-2. - DOI - PMC - PubMed

[8] Greenberg S.M., Bacskai B.J., Hernandez-Guillamon M., Pruzin J., Sperling R., van Veluw S.J. Cerebral amyloid angiopathy and Alzheimer disease—One peptide, two pathways. Nat. Rev. Neurol. 2020;16:30–42. doi: 10.1038/s41582-019-0281-2. - DOI - PMC - PubMed

[9] Ellis R.J., Olichney J.M., Thal L.J., Mirra S.S., Morris J.C., Beekly D., Heyman A. Cerebral amyloid angiopathy in the brains of patients with Alzheimer’s disease: The CERAD experience, Part XV. Neurology. 1996;46:1592–1596. doi: 10.1212/WNL.46.6.1592. - DOI - PubMed

[10] Ellis R.J., Olichney J.M., Thal L.J., Mirra S.S., Morris J.C., Beekly D., Heyman A. Cerebral amyloid angiopathy in the brains of patients with Alzheimer’s disease: The CERAD experience, Part XV. Neurology. 1996;46:1592–1596. doi: 10.1212/WNL.46.6.1592. - DOI - PubMed

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Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease

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Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease

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