Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan-Mar;13(1):100325.
doi: 10.1016/j.jaim.2020.05.010. Epub 2020 May 14.

AYUSH 64, a polyherbal Ayurvedic formulation in Influenza-like illness - Results of a pilot study

Manohar S Gundeti  1 , Laxman W Bhurke  2 , Pallavi S Mundada  2 , Sanjay Murudkar  3 , Ashita Surve  4 , Ramavatar Sharma  5 , Sunita Mata  5 , Rakesh Rana  6 , Richa Singhal  7 , Neera Vyas  8 , Shruti Khanduri  5 , B S Sharma  5 , N Srikanth  9 , K S Dhiman  10
Affiliations

AYUSH 64, a polyherbal Ayurvedic formulation in Influenza-like illness - Results of a pilot study

Manohar S Gundeti et al. J Ayurveda Integr Med. 2022 Jan-Mar.

Abstract

Background: Influenza-like Illness (ILI) refers to a wide range of viral infections with an important cause of morbidity and mortality worldwide. The global incidence of ILI is estimated at 5-10% in adults and 20-30% in children. In India influenza accounts for 20-42% of monthly acute medical illness hospitalizations during the peak rainy season. AYUSH-64, a poly-herbal drug, is in practice for 40 years for various clinical conditions like fevers, microfilaremia, and inflammatory conditions.

Objective: A pilot study was conducted to evaluate the safety and efficacy of Ayurvedic formulation, AYUSH-64 in clinically diagnosed ILI for accelerating the recovery.

Material and methods: A prospective, open-label, nonrandomized, single group, single-center pilot clinical study with pre-test and post-test design was conducted at Raja Ramdeo Anandilal Podar Central Ayurveda Research Institute for Cancer, Mumbai, an institute of Central Council for Research in Ayurvedic Sciences (CCRAS) between June 2018 and July 2019. A total of 38 participants of clinically diagnosed ILI (18-65 years) were studied with an one-week intervention of 'AYUSH 64' in a dose of 3 gm/day and three weeks post-treatment observation period. Assessment of parameters viz. improvement in the symptoms of ILI, frequency of usage of acetaminophen, antihistaminic and cough syrup, hematology, liver function and kidney function tests along with incidence of secondary complications, and time to return to a normal routine was done.

Results: One-week intervention of AYUSH 64 helped to recover from ILI symptoms with reduced frequency of usage of acetaminophen and antihistaminic. The intervention was safe on hematology and biochemical parameters. No serious adverse effects were observed during the study.

Conclusion: AYUSH 64 along-with standard care in ILI is safe and efficacious and this may be used in other viral infections with pyrexia as add-on to standard care for early recovery and better outcome.

Keywords: AYUSH 64; Ayurveda intervention; Efficacy; Influenza-like illness (ILI); Safety; Vata-Kaphaja Jvara.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest Nil.

Figures

Fig. 1
Fig. 1
CONSORT 2010 Flow Diagram.
Fig. 2
Fig. 2
Severity of illness as assessed by mean AUC for Total Symptoms Score.
Fig. 3
Fig. 3
Effect of the trial drug on disease specific Ayurvedic parameters.
See this image and copyright information in PMC

References

    1. Saha S., Gupta V., Dawood F.S., Broor S., Lafond K.E., Chadha M.S., et al. Estimation of community-level influenza-associated illness in a low resource rural setting in India. PLoS One. 2018;13(4) - PMC - PubMed
    1. https://www.cdc.gov/flu/about/viruses/change.htm 11.51pm.
    1. Vaidya Jadavaji T.A., editor. Charaka Samhita of Acharya Charaka, Chikitsa Sthana, Jvara chikitsa, 3rd Chapter, Verse 86-87. 5th ed. Chaukambha Sanskrit Sansthan; Varanasi: 2001. p. 406.
    1. Vaidya Jadavaji T.A., editor. Charaka Samhita of Acharya Charaka, Chikitsa Sthana, Jvara chikitsa, 3rd Chapter, Verse 142-143. 5th ed. Chaukambha Sanskrit Sansthan; Varanasi: 2001. p. 409.
    1. Shankar R., Deb S., Sharma B.K. Antimalarial plants of northeast India: An overview. J Ayurveda Integr Med. 2012 Jan;3(1):10–16. doi: 10.4103/0975-9476.93940. - DOI - PMC - PubMed