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Comment
. 2021 Jan 26;118(4):e2019695118.
doi: 10.1073/pnas.2019695118.

On the utility of CSF1R inhibitors

Kim N Green  1 , David A Hume  2
Affiliations
Comment

On the utility of CSF1R inhibitors

Kim N Green et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

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References

    1. Lei F., et al. , CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages. Proc. Natl. Acad. Sci. U.S.A. 117, 23336–23338 (2020). - PMC - PubMed
    1. Hume D. A., et al. , Phenotypic impacts of CSF1R deficiencies in humans and model organisms. J. Leukoc. Biol. 107, 205–219 (2020). - PubMed
    1. Green K. N., Crapser J. D., Hohsfield L. A., To kill a microglia: A case for CSF1R inhibitors. Trends Immunol. 41, 771–784 (2020). - PMC - PubMed
    1. Valdearcos M., et al. , Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 9, 2124–2138 (2014). - PMC - PubMed
    1. Spangenberg E., et al. , Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model. Nat. Commun. 10, 3758 (2019). - PMC - PubMed

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