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Editorial
. 2021 Feb;28(2):423-426.
doi: 10.1038/s41418-020-00703-w. Epub 2021 Jan 14.

The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities

Rune Busk Damgaard  1
Affiliations
Editorial

The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities

Rune Busk Damgaard. Cell Death Differ. 2021 Feb.
No abstract available

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Conflict of interest statement

The author declares that he has no conflict of interest.

Figures

Fig. 1
Fig. 1. Ubiquitin signalling in cell biology and disease.
A Schematic of the ubiquitination and deubiquitination reactions. Ubiquitination is a sequential cascade of enzymatic reactions. First, ubiquitin (Ub) is attached to the E1 Ub-activating enzyme in an ATP-dependent manner before it is transferred to an E2 Ub-conjugating enzyme. Subsequently, the Ub is transferred from the Ub~E2 conjugate to a lysine residue in a substrate either directly from the E2, mediated by a RING E3 Ub ligase, or first transferred to a HECT/RBR E3 Ub ligase before being transferred to the substrate. Deubiquitination is performed by deubiquitinases (DUBs) that remove ubiquitin modifications from substrates. B Schematic representation and examples of some of the ubiquitin modifications in the ‘ubiquitin code’. C Examples of cellular functions that are regulated by ubiquitination. D Dysfunction or dysregulation of ubiquitination is associated with development of a range of pathologies and human diseases. Recent advances in the understanding of ubiquitin biology at the cellular and molecular level may offer new therapeutic opportunities and strategies for drug development to treat human diseases. HECT Homologous to the E6-AP Carboxyl Terminus, RING really interesting new gene, RBR RING-in-between-RING.
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