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Review
. 2021 Jan 8:14:67-83.
doi: 10.2147/DMSO.S281186. eCollection 2021.

Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products

Jelena Jakab  1   2 , Blaženka Miškić  2   3 , Štefica Mikšić  2 , Brankica Juranić  2   4 , Vesna Ćosić  2 , Dragan Schwarz  2   5 , Aleksandar Včev  2
Affiliations
Review

Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products

Jelena Jakab et al. Diabetes Metab Syndr Obes. .

Abstract

Obesity is recognized as a severe threat to overall human health and is associated with type 2 diabetes mellitus, dyslipidemia, hypertension, and cardiovascular diseases. Abnormal expansion of white adipose tissue involves increasing the existing adipocytes' cell size or increasing the number through the differentiation of new adipocytes. Adipogenesis is a process of proliferation and differentiation of adipocyte precursor cells in mature adipocytes. As a key process in determining the number of adipocytes, it is a possible therapeutic approach for obesity. Therefore, it is necessary to identify the molecular mechanisms involved in adipogenesis that could serve as suitable therapeutic targets. Reducing bodyweight is regarded as a major health benefit. Limited efficacy and possible side effects and drug interactions of available anti-obesity treatment highlight a constant need for finding novel efficient and safe anti-obesity ingredients. Numerous studies have recently investigated the inhibitory effects of natural products on adipocyte differentiation and lipid accumulation. Possible anti-obesity effects of natural products include the induction of apoptosis, cell-cycle arrest or delayed progression, and interference with transcription factor cascade or intracellular signaling pathways during the early phase of adipogenesis.

Keywords: adipogenesis; anti-obesity treatment; bioactive molecules; signaling pathways; transcriptional cascades.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Stages and molecular regulation of adipogenesis.
See this image and copyright information in PMC

References

    1. Ambele MA, Dhanraj P, Giles R, Pepper MS. Adipogenesis: a complex interplay of multiple molecular determinants and pathways. Int J Mol Sci. 2020;21:4283. doi:10.3390/ijms21124283 - DOI - PMC - PubMed
    1. World Health Organization. Obesity and overweight. WHO Newsroom Fact Sheets; 2020. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed August20, 2020.
    1. Matsuda M, Shimomura I. Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Obes Res Clin Pract. 2013;7:e330–e341. doi:10.1016/j.orcp.2013.05.004 - DOI - PubMed
    1. Schmidt FM, Weschenfelder J, Sander C, et al. Inflammatory cytokines in general and central obesity and modulating effects of physical activity. PLoS One. 2015;10:0121971. doi:10.1371/journal.pone.0121971 - DOI - PMC - PubMed
    1. Găman MA, Epîngeac ME, Diaconu CC, Găman AM. Evaluation of oxidative stress levels in obesity and diabetes by the free oxygen radical test and free oxygen radical defence assays and correlations with anthropometric and laboratory parameters. World J Diabetes. 2020;11(5):193–201. doi:10.4239/wjd.v11.i5.193 - DOI - PMC - PubMed