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Review
. 2020 Dec;27(6):7-14.
doi: 10.21315/mjms2020.27.6.2. Epub 2020 Dec 29.

The Effect of Surgical Intervention of Endometriosis to CA-125 and Pain

Abdul Kadir Abdul Karim  1   2 , Nor Haslinda Abd Aziz  1 , Reena Rahayu Md Zin  3 , Norfilza Mohd Mokhtar  2 , Mohamad Nasir Shafiee  1
Affiliations
Review

The Effect of Surgical Intervention of Endometriosis to CA-125 and Pain

Abdul Kadir Abdul Karim et al. Malays J Med Sci. 2020 Dec.

Abstract

Endometriosis is an inflammatory condition characterised by the presence of endometrial growth beyond the uterine cavity. It is a debilitating disease requiring multiple modalities of treatment. In considering surgery as the option of treatment, the benefits should outweigh the risk. Besides direct surgical risk, intervention may lead to a reduction of ovarian reserve, in addition to premature menopause and low fecundity. To date, there is an inconclusive evidence to support any specific parameters in monitoring disease progression following surgical intervention. Serum cancer antigen (CA)-125 is expressed by coelomic epithelium and has been extensively studied as a biomarker for endometriosis. Elevated expression of CA-125 has been shown in endometrial tissues and the marker increased indirectly from peritoneal irritation that accompanies an extensive form of endometriosis. Additionally, the visual analogue scale (VAS) scores have been used as an objective measurement for measuring pain, especially in a complex disease such as endometriosis. This review aims to consolidate a series of clinical trials that utilised CA-125 level and VAS score as tools for monitoring patients undergoing surgery for endometriosis.

Keywords: CA-125; endometriosis; surgery; visual analogue scale.

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Conflict of interest statement

Conflict of Interest We wish to confirm that there are no known conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome.

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