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. 2020 Dec;9(6):2064-2070.
doi: 10.21037/gs-20-797.

The effect of subcutaneous local spraying of Pseudomonas aeruginosa preparation to reduce postoperative drainage time in patients with breast cancer

Quanyi Long  1 , Jia Zhang  1 , Bin Wei  2 , Jiahao Qi  3 , Hongjiang Li  1
Affiliations

The effect of subcutaneous local spraying of Pseudomonas aeruginosa preparation to reduce postoperative drainage time in patients with breast cancer

Quanyi Long et al. Gland Surg. 2020 Dec.

Abstract

Background: To evaluate the efficacy of subcutaneous local spraying of Pseudomonas aeruginosa (P. aeruginosa) preparation (PAP) to reduce the postoperative drainage time in patients with breast cancer (BC).

Methods: The PAP was prepared from an inactivated P. aeruginosa-mannose sensitive hemagglutinin (PA-MSHA) strain, a genetically engineered heat-inactivated PA strain with, mannose-sensitive binding activity, which can induce tumor cell apoptosis. This study is its retrospective nature, a total of 65 BC patients (PAP group) who underwent subcutaneous local spraying of PAP in the operation area at West China Hospital of Sichuan University between June 2019 and October 2019, and 32 BC patients without treatment (non-PAP group, without intraoperative subcutaneous local spraying of PAP in the operation area) were enrolled. Daily drainage volume, drainage time, presence of seroma after extubation, and treatment complications (such as fever, incision infection, and flap necrosis) were recorded.

Results: No significant differences in age, height, weight, age of initial menstruation, menopause, body mass index (BMI), tumor size, lymph node metastasis, or treatment complications were found between the two groups (P>0.05). Drainage volume and drainage time in the PAP group were significantly lower than those in the non-PAP group (P<0.001). Additionally, the incidence of seroma after extubation was significantly lower in the PAP group compared to the non-PAP group (P=0.009).

Conclusions: Subcutaneous local spraying of PAP on the operation area may be helpful to reduce drainage volume, shorten drainage time, and prevent the occurrence of seroma after BC surgery.

Keywords: Breast cancer (BC); Pseudomonas aeruginosa preparation (P. aeruginosa preparation); drainage time; subcutaneous local spraying.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/gs-20-797). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Screening process of study subjects.
Figure 2
Figure 2
Subcutaneous local spraying of P. aeruginosa preparation.
Figure 3
Figure 3
Pseudomonas aeruginosa preparation injection and its outer packaging.
See this image and copyright information in PMC

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