Computer analysis of cardiovascular changes during sleep-wake cycle in Sprague-Dawley rats

Abstract

Blood pressure (BP) and heart rate (HR) were recorded in seven Sprague-Dawley rats during a total of 491 normal sleep-wake cycles with the use of a computer-assisted method developed for this study. Significant changes of BP, HR, and BP variability (BPV) were found between the three states within the cycle, i.e., wakefulness (W), slow-wave sleep (SWS), and paradoxical sleep (PS). The highest BP, BPV, and HR values were found during W. Then all cardiovascular (CV) variables fell during SWS, whereas BP and BPV rose again during PS. The fall of BPV observed during SWS was the most important CV change observed within the cycle. These state-dependent CV changes suggest that, in the rat, circulation during the sleep-wake cycle is controlled by the same central factors that operate in cats. In addition, significant BP and HR modifications between different cycles have been found. On the other hand, BP and HR differences between animals were also observed. The latter differences were found to be stable across the states, but no significant relation was found between BP and HR within any state. Thus the present data also suggest that BP and HR measurements are influenced not only by state-dependent factors but also by at least three different factors that are each independent of the state: one leads to BP and HR values that are influenced by the cycle the animal is in and the other two influence, respectively, the ranking of the individual's BP and HR levels within the population.