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Review
. 2021 Mar;19(3):341-350.
doi: 10.1111/ddg.14389. Epub 2021 Jan 14.

Inherited ichthyosis and fungal infection: an update on pathogenesis and treatment strategies

Huilei Miao  1   2 , Ruijia Dong  1   2 , Shiyu Zhang  1 , Lu Yang  1 , Yuehua Liu  1 , Tao Wang  1
Affiliations
Review

Inherited ichthyosis and fungal infection: an update on pathogenesis and treatment strategies

Huilei Miao et al. J Dtsch Dermatol Ges. 2021 Mar.

Abstract

Inherited ichthyoses are a group of genodermatoses classified as either nonsyndromic or syndromic. Nonsyndromic ichthyoses and keratitis, ichthyosis and deafness (KID) syndrome predispose to fungal infection. The diagnosis and treatment of fungal infections underlying ichthyoses are challenging. In this review, we summarize reported cases of ichthyosis with fungal infection over the past 50 years. Atypical manifestations such as alopecia, papules and brittle nails occurred in patients with ichthyosis combined with fungal infection. Various pathogenic mechanisms have been implicated, including mutations of ichthyosis-related genes leading to disruption of the skin barrier via multiple pathways. Host immune disorders, including atopy and abnormal innate immunity also contribute to susceptibility. Specific fungi may escape the immune response. Extensive and recurrent fungal infections are not uncommon in patients with ichthyosis, making a cure more difficult and increasing the need for systemic antifungal therapy. Traditional and new ichthyosis treatments aiming to improve skin barrier function could help prevent fungal infection. In conclusion, the close relationship between ichthyosis and fungal infection is of vital importance in clinical practice and requires more attention from physicians. More studies are required to investigate the mechanisms and explore useful treatment strategies.

Keywords: KID syndrome; fungal infection; ichthyosis; nonsyndromic ichthyosis.

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References

    1. Oji V, Tadini G, Akiyama M et al. Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Soreze 2009. J Am Acad Dermatol 2010; 63(4): 607-41.
    1. Eldridge ML, Chambers CJ, Sharon VR et al. Fungal infections of the skin and nail: new treatment options. Expert Rev Anti Infect Ther 2014; 12(11): 1389-405.
    1. Vyas NS, Kannan S, M NJ et al. Congenital ichthyosiform erythroderma superimposed with chronic dermatophytosis: a report of three siblings. Pediatr Dermatol 2016; 33(1): e6-9.
    1. Coggshall K, Farsani T, Ruben B et al. Keratitis, ichthyosis, and deafness syndrome: a review of infectious and neoplastic complications. J Am Acad Dermatol 2013; 69(1): 127-34.
    1. Agostini G, Geti V, Difonzo EM et al. Dermatophyte infection in ichthyosis vulgaris. Mycoses 1992; 35(7-8): 197-9.

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