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. 2021 Jan 15;35(1):124-129.
doi: 10.7507/1002-1892.202006068.

[Progress of change in bone mineral density after knee arthroplasty]

[Article in Chinese]
Wenxing Wei  1 , Yuangang Wu  1 , Yi Zeng  1 , Bin Shen  1
Affiliations

[Progress of change in bone mineral density after knee arthroplasty]

[Article in Chinese]
Wenxing Wei et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. .

Abstract
in English, Chinese

Objective: To summarize research progress of change in bone mineral density (BMD) after knee arthroplasty and its diagnostic methods, influencing factors, and drug prevention and treatment.

Methods: The relevant literature at home and abroad was reviewed and summarized from research status of the advantages and disadvantages of BMD assessment methods, the trend of changes in BMD after knee arthroplasty and its influencing factors, and the differences in effectiveness of drugs.

Results: The central BMD and mean BMD around the prosthesis decrease after knee arthroplasty, which is closely associated with body position, age, weight, daily activities, and the fixation methods, design, and material of prosthesis. Denosumab, bisphosphonates, and teriparatide et al. can decrease BMD loss after knee arthroplasty.

Conclusion: BMD after knee arthroplasty decreases, which is related to various factors, but the mechanism is unclear. At present, some inhibitors of bone resorption can decrease BMD loss after knee arthroplasty. However, its long-term efficacy remains to be further explored.

目的: 总结膝关节置换术后骨密度的变化及其诊断方式、影响因素和药物防治研究进展。.

方法: 查阅近年国内外有关文献，对骨密度评估测量方式的优缺点、膝关节置换术后骨密度的变化趋势及其影响因素，以及药物防治疗效差异进行总结。.

结果: 膝关节置换术后全身骨密度及假体周围平均骨密度总体呈下降趋势，与检测时患者体位、年龄、体质量、日常活动、假体固定方式、假体设计以及假体材料等因素密切相关。狄诺塞麦、双膦酸盐和特立帕肽等药物能够减少膝关节置换术后骨密度降低程度。.

结论: 膝关节置换术后骨密度呈下降趋势，但发生机制尚不明确，与多种因素相关。目前，抑制骨吸收药物对于膝关节置换术后骨密度降低有一定效果，但远期疗效有待进一步探究。.

Keywords: Unicompartmental knee arthroplasty; bone loss; bone mineral density; total knee arthroplasty.

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Conflict of interest statement

利益冲突：所有作者声明，在课题研究和文章撰写过程中不存在利益冲突。

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