FUS Is Not Mislocalized in Spinal Motor Neurons Derived From Human Induced Pluripotent Stem Cells of Main Non-FUS ALS Subtypes

Barbara Szewczyk¹, René Günther^{2

3}, Jared Sterneckert⁴, Susanne Petri⁵, Florian Wegner⁵, Andreas Hermann^{1

6

7}

Affiliations

¹ Translational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.
² Deptartment of Neurology, Technische Universität Dresden, Dresden, Germany.
³ German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
⁴ Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.
⁵ Department of Neurology, Hannover Medical School, Hannover, Germany.
⁶ German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Rostock, Germany.
⁷ Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, Rostock, Germany.

Comment

Barbara Szewczyk et al. J Neuropathol Exp Neurol. 2021.

. 2021 Aug 11;80(7):720-722.

doi: 10.1093/jnen/nlaa154.

Barbara Szewczyk¹, René Günther^{2

3}, Jared Sterneckert⁴, Susanne Petri⁵, Florian Wegner⁵, Andreas Hermann^{1

6

7}

¹ Translational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.
² Deptartment of Neurology, Technische Universität Dresden, Dresden, Germany.
³ German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
⁴ Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.
⁵ Department of Neurology, Hannover Medical School, Hannover, Germany.
⁶ German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Rostock, Germany.
⁷ Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, Rostock, Germany.

No abstract available

Comment on

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis.
Tyzack GE, Luisier R, Taha DM, Neeves J, Modic M, Mitchell JS, Meyer I, Greensmith L, Newcombe J, Ule J, Luscombe NM, Patani R. Tyzack GE, et al. Brain. 2019 Sep 1;142(9):2572-2580. doi: 10.1093/brain/awz217. Brain. 2019. PMID: 31368485 Free PMC article.