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Clinical Trial
. 2021 Apr 1;96(4):E111-E114.
doi: 10.1002/ajh.26095. Epub 2021 Jan 31.

Daratumumab in transfusion-dependent patients with low or intermediate-1 risk myelodysplastic syndromes

Guillermo Garcia-Manero  1 , Maria Diez-Campelo  2 , Edo Vellenga  3 , Meagan A Jacoby  4 , Brayan Merchan  5 , Dimitri Breems  6 , Agostino Cortelezzi  7 , Vadim Doronin  8 , Valle Gomez  9 , Marielle Beckers  10 , Matteo Giovanni Della Porta  11 , Helen Varsos  12 , Liang Xiu  12 , Nikki DeAngelis  13 , Ivo Nnane  13 , Esther Rose  12 , Koen van Eygen  14
Affiliations
Free article
Clinical Trial

Daratumumab in transfusion-dependent patients with low or intermediate-1 risk myelodysplastic syndromes

Guillermo Garcia-Manero et al. Am J Hematol. .
Free article
No abstract available

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References

REFERENCES

    1. Chen X, Eksioglu EA, Zhou J, et al. Induction of myelodysplasia by myeloid-derived suppressor cells. J Clin Invest. 2013;123:4595-4611.
    1. Fozza C, Longu F, Contini S, et al. Patients with early-stage myelodysplastic syndromes show increased frequency of CD4+CD25+CD127(low) regulatory T cells. Acta Haematol. 2012;128:178-182.
    1. Smith BD, Roboz GJ, Walter RB, et al. First-in man, phase 1 study of CSL362 (anti-IL3Rα/anti-CD123 monoclonal antibody) in patients with CD123+ acute myeloid leukemia (AML) in CR at high risk for early relapse. Blood. 2014;124:120-120.
    1. Janssen Biotech, Inc. DARZALEX® (daratumumab) [package insert]. Horsham, PA: Janssen Biotech, Inc.; 2020.
    1. Dos Santos C, Xiaochuan S, Chenghui Z, et al. Anti-leukemic activity of daratumumab in acute myeloid leukemia cells and patient-derived xenografts. Blood. 2014;124:2312-2312.

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