An investigation into the relationship between stimulus property, neural response and its manifestation in the visual evoked potential involving retinal resolution

Abstract

The visual evoked potential (VEP) has been shown to reflect the size of the neural population activated by a processing mechanism selective to the temporal - and spatial luminance contrast property of a stimulus. We set out to better understand how the factors determining the neural response associated with these mechanisms. To do so we recorded the VEP from 14 healthy volunteers viewing two series of pattern reversing stimuli with identical temporal-and spatial luminance contrast properties. In one series the size of the elements increased towards the edge of the image, in the other it decreased. In the former element size was congruent with receptive field size across eccentricity, in the later it was incongruent. P100 amplitude to the incongruent series exceeded that obtained to the congruent series. Using electric dipoles due the excitatory neural response we accounted for this using dipole cancellation of electric dipoles of opposite polarity originating in supra- and infragranular layers of V1. The phasic neural response in granular lamina of V1 exhibited magnocellular characteristics, the neural response outside of the granular lamina exhibited parvocellular characteristics and was modulated by re-entrant projections. Using electric current density, we identified areas of the dorsal followed by areas of the ventral stream as the source of the re-entrant signal modulating infragranular activity. Our work demonstrates that the VEP does not signal reflect the overall level of a neural response but is the result of an interaction between electric dipoles originating from neural responses in different lamina of V1.

Keywords: contrast; dipole cancellation; neural components; re-entrant projections; retinotopy.