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Case Reports
. 2021 Jan-Feb;44(1):21-22.
doi: 10.1097/WNF.0000000000000430.

Severe Relapses of Neuromyelitis Optica Spectrum Disorder During Treatment With Dimethyl Fumarate

Nina Javadian  1 , Hana Magrouni, Majid Ghaffarpour, Sakineh Ranji-Burachaloo
Affiliations
Case Reports

Severe Relapses of Neuromyelitis Optica Spectrum Disorder During Treatment With Dimethyl Fumarate

Nina Javadian et al. Clin Neuropharmacol. 2021 Jan-Feb.

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease of the central nervous system, characterized by a specific antibody that selectively binds aquaporin-4 channel.This is a report of an NMOSD case, with severe attacks of optic neuritis and myelitis after initiate of dimethyl fumarate (DMF).We suggested that DMF could deteriorate the neuromyelitis optica (NMO) disease course, which results in serious morbidity and mortality in patients. Thus, initiation of DMF should be avoided before ruling out NMOSD in patients experiencing demyelinating attacks, especially in the case of recurrent optic neuritis or myelopathy and concurrency of other rheumatologic diseases.

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Conflict of interest statement

Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare.

References

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