Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Feb 1;132(2):e29-e31.
doi: 10.1213/ANE.0000000000005279.

Oral Perphenazine 8 mg: A Low-Cost, Efficacious Antiemetic Option

Brian A Williams  1 , Jennifer M Holder-Murray  2 , Stephen A Esper  3 , Kathirvel Subramaniam  3 , Susan J Skledar  4 , Michael L Kentor  3 , Steven L Orebaugh  3 , Michael P Mangione  3 , James W Ibinson  3 , Jonathan H Waters  3 , John P Williams  3 , Jacques E Chelly  3
Affiliations
Comment

Oral Perphenazine 8 mg: A Low-Cost, Efficacious Antiemetic Option

Brian A Williams et al. Anesth Analg. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: K. Subramaniam worked as a consultant for Octapharma in February 2020, and also receives annual royalties for textbooks from Springer. J. P. Williams is on the Board of Directors for the Allegheny County Medical Society, and for the Pennsylvania Medical Society. He is also on the Council for Medical Education for the American Medical Association. He is also on the Board and an investor for a medical marijuana dispensary.

Comment in

  • In Response.
    Jin Z, Gan TJ, Belani KG, Bergese S, Chung F, Diemunsch P, Habib AS, Kovac AL, Meyer TA, Urman RD, Apfel CC, Ayad S, Beagley L, Candiotti K, Englesakis M, Hedrick TL, Kranke P, Lee S, Lipman D, Minkowitz HS, Morton J, Philip BK. Jin Z, et al. Anesth Analg. 2021 Feb 1;132(2):e31-e33. doi: 10.1213/ANE.0000000000005280. Anesth Analg. 2021. PMID: 33449569 No abstract available.

Comment on

  • Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting.
    Gan TJ, Belani KG, Bergese S, Chung F, Diemunsch P, Habib AS, Jin Z, Kovac AL, Meyer TA, Urman RD, Apfel CC, Ayad S, Beagley L, Candiotti K, Englesakis M, Hedrick TL, Kranke P, Lee S, Lipman D, Minkowitz HS, Morton J, Philip BK. Gan TJ, et al. Anesth Analg. 2020 Aug;131(2):411-448. doi: 10.1213/ANE.0000000000004833. Anesth Analg. 2020. PMID: 32467512 Review.

References

    1. Gan TJ, Belani KG, Bergese S, et al. Fourth consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2020;131:411–448. - PubMed
    1. Williams BA, Kentor ML, Skledar SJ, Orebaugh SL, Vallejo MC. Routine multimodal antiemesis including low-dose perphenazine in an ambulatory surgery unit of a university hospital: a 10-year history. Supplement to: Eliminating postoperative nausea and vomiting in outpatient surgery with multimodal strategies including low doses of nonsedating, off-patent antiemetics: Is “zero tolerance” achievable? ScientificWorldJournal. 2007;7:978–986. - PMC - PubMed
    1. Apfel CC, Korttila K, Abdalla M, et al. ; IMPACT Investigators. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med. 2004;350:2441–2451. - PMC - PubMed
    1. Geist ET, Gross BD. Reduction of ketamine-induced emergence phenomena by preoperative promethazine. J Oral Maxillofac Surg. 1982;40:549–550. - PubMed
    1. Henao JP, Peperzak KA, Lichvar AB, et al. Extrapyramidal symptoms following administration of oral perphenazine 4 or 8 mg: an 11-year retrospective analysis. Eur J Anaesthesiol. 2014;31:231–235. - PMC - PubMed