Correction: Significant Determinants of Mouse Pain Behaviour

Abstract

[This corrects the article DOI: 10.1371/journal.pone.0104458.].

Fig 3. Comparison of different transgenic mice reveals stimulus-intensity specific responses to noxious thermal stimuli.

Behavioural responses of different Nav1.7 tissue-specific knockouts to the Hargreaves test applied to the hindpaw. (a) Nav1.7^Nav1.8 mice (blue columns, n  =  14), Nav1.7^Advill mice (red column, n  =  7) and Nav1.7^Wnt1 mice (green column, n  =  12) all show a behavioural deficit in response to the Hargreaves test at a heat ramp of 0.6°C.s⁻¹ in comparison to littermate mice (white columns, n  =  27), however (b) only Nav1.7^Advill and Nav1.7^Wnt1 mice show a behavioural deficit in response to the Hargreaves test at a heat ramp of 2.0°C.s⁻¹. (c) Nav1.8KO mice (light blue column, n  =  6) and Nav1.9KO mice (turquoise column, n  =  10) but not Nav1.3KO mice (orange column, n  =  6) show a significantly increased withdrawal latency to the Hargreaves test at a heat ramp of 0.6°C.s⁻¹ in comparison to littermate mice (white columns, n  =  18), however this significant increase is lost the when the Hargreaves test is conducted using a heat ramp of 2.0°C.s⁻¹. Data analysed by two-way analysis of variance followed by a Bonferroni post-hoc test. Results are presented as mean ± S.E.M. * P<0.05 and *** P<0.001 (individual points).