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Review
. 2021 Jan 13;10(2):268.
doi: 10.3390/jcm10020268.

Could Chronic Idiopatic Intestinal Pseudo-Obstruction Be Related to Viral Infections?

Emanuele Sinagra  1   2 , Gaia Pellegatta  3 , Marcello Maida  4 , Francesca Rossi  1 , Giuseppe Conoscenti  1 , Socrate Pallio  5 , Rita Alloro  6 , Dario Raimondo  1 , Andrea Anderloni  3
Affiliations
Review

Could Chronic Idiopatic Intestinal Pseudo-Obstruction Be Related to Viral Infections?

Emanuele Sinagra et al. J Clin Med. .

Abstract

Chronic idiopathic intestinal pseudo-obstruction (CIIPO) is a disease characterized by symptoms and signs of small bowel obstruction in the absence of displayable mechanical obstruction. Due to the known neuropathic capacity of several viruses, and their localization in the intestine, it has been hypothesized that such viruses could be involved in the pathogenesis of CIIPO. The most frequently involved viruses are John Cunningham virus, Herpesviridae, Flaviviruses, Epstein-Barr virus and Citomegalovirus. Therefore, the present narrative review aims to sum up some new perspectives in the etiology and pathophysiology of CIIPO.

Keywords: chronic idiopathic intestinal pseudo-obstruction; gastrointestinal motility disorders; virus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Pathogenesis if varicella-zoster infection is present. ENS: enteric nervous system; VZV: varicella-zoster virus.
Figure 2
Figure 2
Pathogenesis if Epstein-Barr virus is present. ENS: enteric nervous system; EBV: Epstein-Barr virus.
See this image and copyright information in PMC

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