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. 2021 Jan 13;11(1):50.
doi: 10.3390/life11010050.

Obstructive Sleep Apnea as a Risk Factor of Insulin Resistance in Nondiabetic Adults

Monika Michalek-Zrabkowska  1 , Piotr Macek  1 , Helena Martynowicz  1 , Pawel Gac  2 , Grzegorz Mazur  1 , Magda Grzeda  1 , Rafal Poreba  1
Affiliations

Obstructive Sleep Apnea as a Risk Factor of Insulin Resistance in Nondiabetic Adults

Monika Michalek-Zrabkowska et al. Life (Basel). .

Abstract

Objective: The aim of this research was to assess the relationship between prevalence and severity of obstructive sleep apnea (OSA) and insulin resistance among patients with increased risk of OSA without diabetes mellitus.

Method and materials: our study group involved 102 individuals with suspected OSA, mean age 53.02 ± 12.37 years. Data on medical history, medication usage, sleep habits, sleep quality and daytime sleepiness, were obtained using questionnaires. All patients underwent standardized full night polysomnography. Serum fasting insulin and glucose concentration were analyzed, the homeostatic model assessment-insulin resistance (HOMA-IR) index was calculated.

Results: polysomnographic study indicated that in the group with OSA mean values of apnea-hypopnea index (AHI), oxygen desaturation index (ODI), duration of SpO2 < 90% and average desaturation drop were significantly higher compared to the group without OSA, while the minimum SpO2 was significantly lower. The carbohydrate metabolism parameters did not differ within those groups. Significantly higher fasting insulin concentration and HOMA-IR index were found in the group with AHI ≥ 15 compared to the group with AHI < 15 and in the group with AHI ≥ 30 compared to the group with AHI < 30. Higher AHI and ODI were independent risk factors for higher fasting insulin concentration and higher HOMA-IR index. Increased duration of SpO2 < 90% was an independent risk factor for higher fasting glucose concentration.

Conclusions: Individuals with moderate to severe OSA without diabetes mellitus had a higher prevalence of insulin resistance.

Keywords: insulin resistance; nondiabetic patients; obstructive sleep apnea.

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Conflict of interest statement

The authors declare no conflict of interest.

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