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. 2021 Jan 15;27(1):3.
doi: 10.1186/s40885-021-00161-7.

Should all patients with hypertension be worried about developing severe coronavirus disease 2019 (COVID-19)?

Ramin Hosseinzadeh  1 , Mohammad Ali Sheikh Beig Goharrizi  2 , Mansour Bahardoust  3   4 , Akbar Ghorbani Alvanegh  5 , Mohammad Reza Ataee  6 , Mehdi Bagheri  7 , Ensiyeh Shabani Navidiyan  8 , Seyed Reza Hosseini Zijoud  9 , Mohammad Heiat  10
Affiliations

Should all patients with hypertension be worried about developing severe coronavirus disease 2019 (COVID-19)?

Ramin Hosseinzadeh et al. Clin Hypertens. .

Abstract

Background: Hypertension, the most common comorbidity among coronavirus disease 2019 (COVID-19) patients, is accompanied by worse clinical outcomes, but there is lack of evidence about prognostic factors among COVID-19 patients with hypertension. We have come up with some prognostic factors to predict the severity of COVID-19 among hypertensive patients. In addition, epidemiologic, clinical and laboratory differences among COVID-19 patients with and without underlying hypertension were evaluated.

Methods: Medical profiles of 598 COVID-19 cases were analyzed. Patients were divided into two comparative groups according to their positive or negative history of hypertension. Then, epidemiologic, clinical, laboratory and radiological features and also clinical outcomes were compared.

Results: 176 (29.4%) patients had underlying hypertension. Diabetes was significantly higher in hypertensive group [72 (40.9%) vs 76 (18%)] (P-value: 0.001). Cardiovascular and renal disorders were significantly higher in hypertensive patients. (P-value: 0.001 and 0.013 respectively). In COVID-19 patients with hypertension, severe/critical types were significantly higher. [42(23.8%) vs. 41(9.7%)], (P-value: 0.012). In the logistic regression model, Body mass index > 25 (ORAdj: 1.8, 95% CI: 1.2 to 2.42; P-value: 0.027), age over 60 (ORAdj: 1.26, 95% CI: 1.08 to 1.42; P-value: 0.021), increased hospitalization period (ORAdj: 2.1, 95% CI: 1.24 to 2.97; P-value: 0.013), type 2 diabetes (ORAdj: 2.22, 95% CI: 1.15 to 3.31; P-value: 0.001) and chronic kidney disease (ORAdj: 1.83, 95% CI: 1.19 to 2.21; P-value: 0.013) were related with progression of COVID-19.

Conclusion: Hypertensive patients with Age > 60-year-old, BMI > 25 Kg/m2, CVD, diabetes and chronic kidney disease are associated with poor outcomes in those with COVID-19 infection.

Keywords: Hypertension; Risk factor; Severe COVID-19.

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Conflict of interest statement

The authors have no conflicts of interest to declare for this study.

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