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. 2021 Aug;88(8):753-756.
doi: 10.1007/s12098-020-03649-6. Epub 2021 Jan 16.

The FeNO Normal Value Analysis of Healthy Children Aged 6-15 Years Old in Chengdu

Tao Ai  1 , Ronghua Luo  2 , Lei Zhang  2 , Li Wang  2 , Huiling Liao  2 , Yinghong Fan  2 , Yaping Duan  2 , Yijie Huang  2
Affiliations

The FeNO Normal Value Analysis of Healthy Children Aged 6-15 Years Old in Chengdu

Tao Ai et al. Indian J Pediatr. 2021 Aug.

Abstract

Objective: To investigate the fractional exhaled nitric oxide (FeNO) normal value of healthy children, and provide a reliable theoretical basis for clinical diagnosis.

Methods: 481 healthy children aged 6-15-y-old in three primary schools in Chengdu were subjected for FeNO detection. Through the statistical analysis, the upper limit normal value of FeNO among the healthy children was obtained, and the related influencing factors of FeNO value were analyzed.

Results: Among the 481 heathy children, the geometric mean value of FeNO was 14.59 ppb (minimum value was 5 ppb, maximum value was 69 ppb), and the upper limit of normal value was 28 ppb. The age, height, and weight all have significant correlations with FeNO.

Conclusion: The upper limit of FeNO in healthy children aged 6-15-y-old was 28.0 ppb. Inflammation in the airway was suggested when the value of FeNO exceeds 28.0 ppb. Furthermore, the influencing factors such as age, weight, height must be considered.

Keywords: Children; Fractional exhaled nitric oxide (FeNO); Normal value.

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Comment in

  • Normal FeNO: What Do We Know?
    Mathew JL, Kumar K. Mathew JL, et al. Indian J Pediatr. 2021 Aug;88(8):743-744. doi: 10.1007/s12098-021-03819-0. Epub 2021 Jun 7. Indian J Pediatr. 2021. PMID: 34097236 No abstract available.

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