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Review
. 2021 Jun;16(4):815-830.
doi: 10.1007/s11739-020-02616-5. Epub 2021 Jan 16.

A narrative review of coronavirus disease 2019 (COVID-19): clinical, epidemiological characteristics, and systemic manifestations

Arunkumar Krishnan  1 , James P Hamilton  2 , Saleh A Alqahtani  2   3 , Tinsay A Woreta  4
Affiliations
Review

A narrative review of coronavirus disease 2019 (COVID-19): clinical, epidemiological characteristics, and systemic manifestations

Arunkumar Krishnan et al. Intern Emerg Med. 2021 Jun.

Abstract

Coronavirus disease 2019 (COVID-19) is an emerging infectious disease which has had a rapid surge in cases and deaths since it is first documented in Wuhan, China, in December 2019. COVID-19 is caused by the Betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses angiotensin-converting enzyme 2, which is highly expressed in the human lower respiratory tract but also in other tissues, as the cellular entry receptor. Thus, COVID-19 mainly affects the respiratory system but can cause damage to other body systems, including the cardiovascular, gastrointestinal, hepatobiliary, renal, and central nervous systems. We review the pathogenesis and clinical manifestations of the infection, focusing on our current understanding of the disease mechanisms and their translation to clinical outcomes, as well as adverse effects on different body systems. We also discuss the epidemiology pathogenesis, clinical, and multi-organ consequences, and highlight some of the research gaps regarding COVID-19.

Keywords: COVID-19; Clinical symptoms; Coronavirus; Epidemiology; SARS-CoV-2; Transmission.

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Conflict of interest statement

All the authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Pathogenesis and the interaction of the viral spike (S)-protein with angiotensin-converting enzyme 2 receptor (ACE2): (1) S proteins on the surface of
Fig. 2
Fig. 2
Gastrointestinal symptoms in patients with COVID-19
See this image and copyright information in PMC

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