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Review
. 2021 Apr 1:124:88-107.
doi: 10.1016/j.actbio.2021.01.010. Epub 2021 Jan 14.

Biomaterial-based extracellular vesicle delivery for therapeutic applications

Vishnu Priya Murali  1 , Christina A Holmes  2
Affiliations
Review

Biomaterial-based extracellular vesicle delivery for therapeutic applications

Vishnu Priya Murali et al. Acta Biomater. .

Abstract

Extracellular vesicle (EV)- based therapies have been successfully tested in preclinical models for several biomedical applications, including tissue engineering, drug delivery and cancer therapy. However, EVs are most commonly delivered via local or systemic injection, which results in rapid clearance. In order to prolong the retention of EVs at target site and improve their therapeutic efficacy, biomaterial-based delivery systems are being investigated. This review discusses the various biomaterial-based systems that have been used to deliver EVs for therapeutic applications, specifically highlighting any strategies for controlled release. Further, challenges to clinical translation of biomaterial-based EV delivery systems are also discussed.

Keywords: Biomaterials; Drug delivery; Extracellular vesicles; Regenerative medicine; Tissue engineering.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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