URINARY EXCRETION OF TGF-Β1 AND VEGF IN CHILDREN WITH VESICOURETERAL REFLUX

Abstract

Objective: The aim of this study was to investigate the relation between urinary TGF-β1, urinary VEGF and renal scarring resulted from VUR.

Patients and methods: Materials and methods: This study included 141 patients with VUR and 34 healthy sex and age matched children. The statistical analysis consisted of descriptive statistical parameters, KruskalWallis, Mann-Whitney tests and ROC analysis.

Results: Results: The urine levels of TGF-β1 and VEGF were significantly increased in children with VUR, compared to the controls. The levels of TGF-β1 urine excretion in children with renal scarring were higher compared children no renal scarring. The indicators of VEGF urine excretion in children with renal scarring compared to indicators in children no renal scarring, were lower, however exceeded the indicators in children of control group. The area under the ROC curve for TGF-β1 was 109.9, for VEGF was 207.6.

Conclusion: Conclusions: The study allowed to substantiate and propose non-invasive methods for early diagnosis of renal scarring in children with VUR.

Keywords: TGF-β1; VEGF; children; renal scarring; vesicoureteral reflux.