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Editorial
. 2021 Feb 14;42(7):786-788.
doi: 10.1093/eurheartj/ehaa979.

Heart failure and systolic function: time to leave diagnostics based on ejection fraction?

Otto A Smiseth  1 , John M Aalen  1   2 , Helge Skulstad  1
Affiliations
Editorial

Heart failure and systolic function: time to leave diagnostics based on ejection fraction?

Otto A Smiseth et al. Eur Heart J. .
No abstract available

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Figures

Graphical abstract
Graphical abstract
(A and B) Prediction of 1-year mortality by LVEF measured during rest (A) and by maximum cardiac power during dobutamine stress (B) in patients with severe acute or chronic heart failure. Means ± SD. For LVEF, there is considerable overlap, whereas maximum cardiac power differentiates well between survivors and non-survivors. An open circle indicates cardiac transplanted and open squares indicate sudden deaths. Modified from Tan. (C) Data from the SHOCK Trial Registry showing that cardiac power was a strong predictor of mortality in cardiogenic shock. Modified from Fincke et al. (D) Five-year mortality was similar in heart failure patients with preserved, borderline, and reduced ejection fraction. Modified from Shah et al. (E) Illustration of a patient during stress echocardiography with a semi-supine bicycle. (F) Five-year Kaplan–Meier survival curves for mortality stratified by quartiles of peak stress cardiac power/mass. Patients with the lowest cardiac power/mass in quartile 1 had the worst survival followed by quartiles 2 and 3, and was the best in quartile 4. Adjusted for age, sex, peak metabolic equivalents, diabetes mellitus, and diastolic function at baseline. Reproduced from Anand et al.
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References

    1. Anand V, Kane GC, Scott CG, Pislaru SV, Adigun RO, McCully RB, Pellikka PA, Pislaru C. Prognostic value of peak stress cardiac power in patients with normal ejection fraction undergoing exercise stress echocardiography. Eur Heart J 2021;42:777–786. - PubMed
    1. Aurigemma GP, Silver KH, Priest MA, Gaasch WH. Geometric changes allow normal ejection fraction despite depressed myocardial shortening in hypertensive left ventricular hypertrophy. J Am Coll Cardiol 1995;26:195–202. - PubMed
    1. Stokke TM, Hasselberg NE, Smedsrud MK, Sarvari SI, Haugaa KH, Smiseth OA, Edvardsen T, Remme EW. Geometry as a confounder when assessing ventricular systolic function: comparison between ejection fraction and strain. J Am Coll Cardiol 2017;70:942–954. - PubMed
    1. Morris DA, Ma XX, Belyavskiy E, Aravind Kumar R, Kropf M, Kraft R, Frydas A, Osmanoglou E, Marquez E, Donal E, Edelmann F, Tschöpe C, Pieske B, Pieske-Kraigher E. Left ventricular longitudinal systolic function analysed by 2D speckle-tracking echocardiography in heart failure with preserved ejection fraction: a meta-analysis. Open Heart 2017;4:e000630. - PMC - PubMed
    1. Shah AM, Claggett B, Sweitzer NK, Shah SJ, Anand IS, Liu L, Pitt B, Pfeffer MA, Solomon SD. Prognostic importance of impaired systolic function in heart failure with preserved ejection fraction and the impact of spironolactone. Circulation 2015;132:402–414. - PMC - PubMed