Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Mar;40(1):3-5.
doi: 10.1007/s10555-021-09955-5.

Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?

Gábor Tigyi  1   2 , Mélanie A Dacheux  3 , Kuan-Hung Lin  3 , Junming Yue  4 , Derek Norman  3 , Zoltán Benyó  5 , Sue Chin Lee  3
Affiliations
Editorial

Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?

Gábor Tigyi et al. Cancer Metastasis Rev. 2021 Mar.

Erratum in

No abstract available

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Seo EJ, Kwon YW, Jang IH, Kim DK, Lee SI, Choi EJ, Kim KH, Suh DS, Lee JH, Choi KU, Lee JW, Mok HJ, Kim KP, Matsumoto H, Aoki J, Kim JH. Autotaxin regulates maintenance of ovarian cancer stem cells through lysophosphatidic acid-mediated autocrine mechanism. Stem Cells. 2016;34(3):551–564. doi: 10.1002/stem.2279. - DOI - PubMed
    1. Tigyi GJ, Yue J, Norman DD, Szabo E, Balogh A, Balazs L, Zhao G, Lee SC. Regulation of tumor cell - microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis. Adv Biol Regul. 2019;71:183–193. doi: 10.1016/j.jbior.2018.09.008. - DOI - PMC - PubMed
    1. Brindley, D. N., Tang, X., Meng, G., & Benesch, M. G. K. (2020). Role of adipose tissue-derived autotaxin, lysophosphatidate signaling, and inflammation in the progression and treatment of breast cancer. International Journal of Molecular Sciences, 21(16). 10.3390/ijms21165938. - PMC - PubMed
    1. Leblanc R, Lee SC, David M, Bordet JC, Norman DD, Patil R, Miller D, Sahay D, Ribeiro J, Clézardin P, Tigyi GJ, Peyruchaud O. Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone. Blood. 2014;124(20):3141–3150. doi: 10.1182/blood-2014-04-568683. - DOI - PMC - PubMed
    1. Auciello FR, Bulusu V, Oon C, Tait-Mulder J, Berry M, Bhattacharyya S, Tumanov S, Allen-Petersen BL, Link J, Kendsersky ND, Vringer E, Schug M, Novo D, Hwang RF, Evans RM, Nixon C, Dorrell C, Morton JP, Norman JC, Sears RC, Kamphorst JJ, Sherman MH. A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discovery. 2019;9(5):617–627. doi: 10.1158/2159-8290.Cd-18-1212. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources