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Editorial
. 2021 Mar;40(1):3-5.
doi: 10.1007/s10555-021-09955-5.

Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?

Gábor Tigyi  1   2 , Mélanie A Dacheux  3 , Kuan-Hung Lin  3 , Junming Yue  4 , Derek Norman  3 , Zoltán Benyó  5 , Sue Chin Lee  3
Affiliations
Editorial

Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?

Gábor Tigyi et al. Cancer Metastasis Rev. 2021 Mar.

Erratum in

No abstract available

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References

    1. Seo EJ, Kwon YW, Jang IH, Kim DK, Lee SI, Choi EJ, Kim KH, Suh DS, Lee JH, Choi KU, Lee JW, Mok HJ, Kim KP, Matsumoto H, Aoki J, Kim JH. Autotaxin regulates maintenance of ovarian cancer stem cells through lysophosphatidic acid-mediated autocrine mechanism. Stem Cells. 2016;34(3):551–564. doi: 10.1002/stem.2279. - DOI - PubMed
    1. Tigyi GJ, Yue J, Norman DD, Szabo E, Balogh A, Balazs L, Zhao G, Lee SC. Regulation of tumor cell - microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis. Adv Biol Regul. 2019;71:183–193. doi: 10.1016/j.jbior.2018.09.008. - DOI - PMC - PubMed
    1. Brindley, D. N., Tang, X., Meng, G., & Benesch, M. G. K. (2020). Role of adipose tissue-derived autotaxin, lysophosphatidate signaling, and inflammation in the progression and treatment of breast cancer. International Journal of Molecular Sciences, 21(16). 10.3390/ijms21165938. - PMC - PubMed
    1. Leblanc R, Lee SC, David M, Bordet JC, Norman DD, Patil R, Miller D, Sahay D, Ribeiro J, Clézardin P, Tigyi GJ, Peyruchaud O. Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone. Blood. 2014;124(20):3141–3150. doi: 10.1182/blood-2014-04-568683. - DOI - PMC - PubMed
    1. Auciello FR, Bulusu V, Oon C, Tait-Mulder J, Berry M, Bhattacharyya S, Tumanov S, Allen-Petersen BL, Link J, Kendsersky ND, Vringer E, Schug M, Novo D, Hwang RF, Evans RM, Nixon C, Dorrell C, Morton JP, Norman JC, Sears RC, Kamphorst JJ, Sherman MH. A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discovery. 2019;9(5):617–627. doi: 10.1158/2159-8290.Cd-18-1212. - DOI - PMC - PubMed

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