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Review
. 2020;58(6):401-406.
doi: 10.5114/reum.2020.102004. Epub 2020 Dec 23.

Ocular manifestations in patients with systemic sclerosis

Małgorzata Kozikowska  1 , Wojciech Luboń  2 , Eugeniusz J Kucharz  3 , Ewa Mrukwa-Kominek  2
Affiliations
Review

Ocular manifestations in patients with systemic sclerosis

Małgorzata Kozikowska et al. Reumatologia. 2020.

Abstract

Systemic sclerosis (SSc) is a rare, chronic autoimmune disease with unknown etiology. Its prominent features are fibrosis, vasculopathy and impaired immune response. Disease can also affect eyes leading to various findings in ophthalmological examination. The objective of this study was to determine the prevalence and type of ocular involvement in patients with SSc. A systematic literature review was conducted using electronic databases. A combination of following keywords was used: "systemic sclerosis" and ophthalmology-related search terms, including the keywords "eye", "ocular" and "ophthalmic". In conclusion, eyelid and conjunctival abnormalities and dry eye disease are among the most common ocular manifestations of SSc. Their diversity is connected to complexity of the disease.

Keywords: dry eye disease; eyelid changes; ocular manifestations; systemic sclerosis.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Varga J, Denton CP, Wigley FM, et al. Scleroderma: from pathogenesis to comprehensive management. 2nd ed. New York: Springer; 2017.
    1. Hachulla E, Czirják L, editors. EULAR Textbook on systemic sclerosis. London: BMJ Publishing Group; 2013.
    1. Kucharz EJ, Kopeć-Mędrek M. Systemic sclerosis sine scleroderma. Adv Clin Exp Med. 2017;26:875–880. doi: 10.17219/acem/64334. - DOI - PubMed
    1. Bellando-Randone S, Matucci-Cerinic M. Very Early Systemic Sclerosis and Pre-systemic Sclerosis: definition, recognition, clinical relevance and future directions. Curr Rheumatol Rep. 2017;19:65. doi: 10.1007/s11926-017-0684-2. - DOI - PubMed
    1. Horimoto AMC, de Macedo Possamai V, da Costa IP. Sjögren’s Syndrome and Sicca Symptoms in Patients with Systemic Sclerosis. J Arthritis. 2016;5:190. doi: 10.4172/2167-7921.1000190. - DOI