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Review
. 2019 Sep;19(9):290-296.
doi: 10.1016/j.bjae.2019.05.005. Epub 2019 Jul 5.

Vitamin C and thiamine in critical illness

Affiliations
Review

Vitamin C and thiamine in critical illness

A M E Spoelstra-de Man et al. BJA Educ. 2019 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors received a grant from the Netherlands Organisation for Health Research and Development to perform a multicentre trial to investigate the effect of high-dose i.v. vitamin C in post-cardiac arrest syndrome.

Figures

Fig 1
Fig 1
Causes of vitamin C and thiamine deficiencies in critical illness.
Fig 2
Fig 2
Pleiotropic and synergistic effects of vitamin C and thiamine. GABA, γ-aminobutyric acid.

References

    1. Marik P.E., Khangoora V., Rivera R., Hooper M.H., Catravas J. Hydrocortisone, vitamin C and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study. Chest. 2017;151:1229–1238. - PubMed
    1. van Zanten A.R., Sztark F., Kaisers U.X. High-protein enteral nutrition enriched with immune-modulating nutrients vs standard high-protein enteral nutrition and nosocomial infections in the ICU: a randomized clinical trial. JAMA. 2014;312:514–524. - PubMed
    1. Carr A.C., Rosengrave P.C., Bayer S., Chambers S., Mehrtens J., Shaw G.M. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care. 2017;21:300. - PMC - PubMed
    1. Borrelli E., Roux-Lombard P., Grau G.E. Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk. Crit Care Med. 1996;24:392–397. - PubMed
    1. de Grooth H.J., Spoelstra-de Man A.M.E., Oudemans-van Straaten H.M. Early plasma vitamin C concentration, organ dysfunction and ICU mortality. Intensive Care Med. 2014;40(Suppl. 1):S199.